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. 2022 Oct;127(7):1296-1303.
doi: 10.1038/s41416-022-01907-2. Epub 2022 Jul 15.

Anthropometric traits and risk of multiple myeloma: a pooled prospective analysis

Kimberly A Bertrand  1 , Lauren R Teras  2 , Emily L Deubler  2 , Chun R Chao  3 , Bernard A Rosner  4   5 , Ke Wang  4 , Charlie Zhong  6   7 , Sophia S Wang  6 , Brenda M Birmann  4
Affiliations

Anthropometric traits and risk of multiple myeloma: a pooled prospective analysis

Kimberly A Bertrand et al. Br J Cancer. 2022 Oct.

Abstract

Background: Obesity is a risk factor for multiple myeloma (MM), yet results of prior studies have been mixed regarding the importance of early and/or later adult obesity; other measures of body composition have been less well studied.

Methods: We evaluated associations of early adult (ages 18-21) and usual adult body mass index (BMI), waist circumference, and predicted fat mass with MM by pooling data from six U.S. prospective cohort studies comprising 544,016 individuals and 2756 incident diagnoses over 20-37 years of follow-up. We used Cox proportional hazards models to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for associations, adjusted for age and other risk factors.

Results: Each 5 kg/m2 increase in usual adult BMI was associated with a 10% increased risk of MM (HR: 1.10; 95% CI: 1.05-1.15). Positive associations were also noted for early adult BMI (HR per 5 kg/m2: 1.14; 95% CI: 1.04-1.25), height (HR per 10 cm: 1.28; 95% CI: 1.20-1.37), waist circumference (HR per 15 cm: 1.09; 95% CI: 1.00-1.19), and predicted fat mass (HR per 5 kg: 1.06; 95% CI: 1.01-1.11).

Conclusions: These findings highlight the importance of avoidance of overweight/obesity and excess adiposity throughout adulthood as a potential MM risk-reduction strategy.

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Conflict of interest statement

The authors declare no competing interests.

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