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. 2022 Apr 12;68(3):93-104.
doi: 10.14341/probl12854.

Course of Cushing`s disease and treatment outcomes in correlation with pituitary MRI in children

E A Yanar  1 , N V Makazan  1 , M A Kareva  1 , A V Vorontsov  1 , V P Vladimirova  1 , O B Bezlepkina  1 , V A Peterkova  1
Affiliations

Course of Cushing`s disease and treatment outcomes in correlation with pituitary MRI in children

E A Yanar et al. Probl Endokrinol (Mosk). .

Abstract

Background: Cushing's disease (CD) is a rare disorder of a persistent cortisol excess caused by ACTH-secreting pituitary tumor (corticotropinoma). Transsphenoidal surgery (TSS) is a treatment of choice for СD, which effectiveness range is from 70 to 90%. Recurrence rate after successful treatment is about 25%. If surgical treatment is unsuccessful or recurrence appear, radiation treatment is the next therapeutic option, which effectiveness range is also 90%, but the hypopituitarism rate as side effect of treatment is higher. Preoperative predictors of remission and recurrence are still unexplored what leads to further investigations.

Aim: Analysis of remission and recurrence rates of pediatric CD after successful treatment according to preoperative MRI and therapeutic option.

Materials and methods: We conducted a retrospective analysis of 90 pediatric patients with CD who were observed between 1992 and 2020 at the Endocrinology Research Centre.

Results: The most common clinical symptoms of CD were weight gain [94%] and growth retardation [72%]. Pituitary tumor was detected on radiological imaging in 53/90 patients [59%], there were no signs of visible adenoma in 37/90 of patients [41%]. 63 of 90 patients underwent TSS (70%), 27 patients underwent radiosurgery (30%). Remission rate after TSS was 71% [45/63], after radiosurgery - 85% [23/27]. There were no significant differences in remission rates after radical treatment according to preoperative MRI results (P=0.21 after TSS and P=0.87 after radiosurgery, х2 analysis). Recurrence after successful treatment was diagnosed in 10 patients. There were no significant differences in time to recurrence according to preoperative MRI results (P=0.055, х2 analysis). Time to recurrence was statistically different after TSS compared to radiosurgery (P=0.007, Kaplan-Meier analysis) and in the group with developed adrenal insufficiency in the early postoperative period (P=0.04, Kaplan-Meier analysis). Analysis of side effect of treatment showed that the frequency of growth hormone and gonadotrophin deficiency was statistically higher after radiosurgery (р<0.01, Kruskel-Wallis ANOVA test). Diabetes insipidus was diagnosed only after TSS.

Conclusion: Results of our study didn`t allow to use MRI-results as predictor of effectiveness treatment in pediatric CD. Therapeutic option has an impact on time to recurrence, not on recurrence rates. The frequency of growth hormone and gonadotrophin deficiency was statistically higher after radiosurgery compared to TSS. Further studies are needed to identify predictors of remission and recurrence in CD.>< 0.01, Kruskel-Wallis ANOVA test). Diabetes insipidus was diagnosed only after TSS.

Conclusion: Results of our study didn`t allow to use MRI-results as predictor of effectiveness treatment in pediatric CD. Therapeutic option has an impact on time to recurrence, not on recurrence rates. The frequency of growth hormone and gonadotrophin deficiency was statistically higher after radiosurgery compared to TSS. Further studies are needed to identify predictors of remission and recurrence in CD.

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Figures

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Рисунок 1. Время до рецидива в подгруппах, сформированных в зависимости от МРТ-характеристик аденом гипофиза (кривые Каплана–Майера, n=90). Группа 1 — пациенты с неоднородностью гипофиза (n=37, рецидив у 2 пациентов), группа 2 — с микроаденомой гипофиза (n=40, рецидив у 5 пациентов), группа 3 — с макроаденомой гипофиза (n=13, рецидив у 3 пациентов). Среднее время до наступления рецидива: 1-я группа — 4,1 года, 2-я группа — 4,1 года, 3-я группа — 3 года.
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Рисунок 2. Время до рецидива в подгруппах, сформированных в зависимости от метода лечения (кривые Каплана–Майера, n=90). Группа 1 — пациенты после хирургического лечения (n=55, рецидив у 8 пациентов), группа 2 — после лучевого лечения на одном из этапов (n=36, рецидив у 2 пациентов). Среднее время до наступления рецидива: 1-я группа — 3,3 года, 2-я группа — 6 лет.
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Рисунок 3. Время до рецидива в подгруппах, сформированных в зависимости от развития гипокортицизма после радикального лечения (кривые Каплана–Майера, n=63). Группа 0 — пациенты, не развившие гипокортицизм (n=23, рецидив у 4 пациентов), группа 1 — развившие транзиторный или стойкий гипокортицизм (n=38, рецидив у 5 пациентов). Среднее время до наступления рецидива: 0-я группа — 3,56 года, 1-я группа — 2,65 года.
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