Prevalence of, and risk factors for, dental sequelae in adolescents who underwent cancer therapy during childhood
- PMID: 35841375
- DOI: 10.1111/odi.14317
Prevalence of, and risk factors for, dental sequelae in adolescents who underwent cancer therapy during childhood
Abstract
Introduction: The increase in survival rates in children treated for cancer has been accompanied by a rise in sequelae in permanent teeth. The aim of the study was to correlate the type of cancer therapy administered to patients during early childhood and the dental sequelae recorded in survivors.
Material and methods: Single-center retrospective cohort study carried out at the Children's University Hospital of Sant Joan de Déu in Barcelona, Spain. Hundred and nine patients who had received cancer treatment during early childhood were randomly examined and grouped according to diagnosis and cancer therapy received. The type of therapy was correlated with the number and severity of dental lesions that patients presented in adolescence.
Results: Dental sequelae of some kind were present in 85.3% of patients. Microdontia was the most prevalent (52.3%). Treatment with alkylating agents had a relative risk of presenting moderate lesions of 3.36 (1.18-9.60), and one of 2.29 (1.07-4.91) of presenting severe lesions. Topoisomerase inhibitors and cytotoxic antibiotics presented relative risks of 1.6 (1.07-2.38) and 2.08 (1.02-4.26) of root alterations and agenesis, respectively.
Conclusions: Treatment with alkylating agents together with cytotoxic antibiotics and topoisomerase inhibitors was associated with a higher relative risk of microdontia, agenesis, and root shortening.
Keywords: adverse effects; chemotherapy; childhood cancer survivors; odontogenic disorders; tooth formation anomalies.
© 2022 The Authors. Oral Diseases published by Wiley Periodicals LLC.
References
REFERENCES
-
- Busenhart, D. M., Erb, J., Rigakos, G., Eliades, T., & Papageorgiou, S. N. (2018). Adverse effects of chemotherapy on the teeth and surrounding tissues of children with cancer: A systematic review with meta-analysis. Oral Oncology, 83, 64-72. https://doi.org/10.1016/j.oraloncology.2018.06.001
-
- Çetiner, D., Çetiner, S., Uraz, A., Alpaslan, G. H., Alpaslan, C., Toygar Memikoğlu, T. U., & Karadeniz, C. (2019). Oral and dental alterations and growth disruption following chemotherapy in long-term survivors of childhood malignancies. Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer, 27(5), 1891-1899. https://doi.org/10.1007/s00520-018-4454-0
-
- Dury, D. C., Roberts, M. W., Miser, J. S., & Folio, J. (1984). Dental root agenesis secondary to irradiation therapy in a case of rhabdomyosarcoma of the middle ear. Oral Surgery, Oral Medicine, and Oral Pathology, 57(6), 595-599. https://doi.org/10.1016/0030-4220(84)90278-0
-
- Effinger, K. E., Migliorati, C. A., Hudson, M. M., McMullen, K. P., Kaste, S. C., Ruble, K., Guilcher, G. M., Shah, A. J., & Castellino, S. M. (2014). Oral and dental late effects in survivors of childhood cancer: A Children's oncology group report. Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer, 22(7), 2009-2019. https://doi.org/10.1007/s00520-014-2260-x
-
- Elzembely, M. M., Dahlberg, A. E., Pinto, N., Leger, K. J., Chow, E. J., Park, J. R., Carpenter, P. A., & Baker, K. S. (2019). Late effects in high-risk neuroblastoma survivors treated with high-dose chemotherapy and stem cell rescue. Pediatric Blood & Cancer, 66(1), e27421. https://doi.org/10.1002/pbc.27421
