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. 2022 Oct;37(5):765-768.
doi: 10.1016/j.virs.2022.07.005. Epub 2022 Jul 13.

HCV 6a was expanding and became the predominant subtype among blood donors between 2004 and 2019 in Guangdong, China

Rongsong Du  1 , Ru Xu  1 , Jieting Huang  1 , Hao Wang  1 , Min Wang  1 , Qiao Liao  1 , Zhengang Shan  1 , Huishan Zhong  1 , Yourong Zheng  1 , Xia Rong  2 , Yongshui Fu  3
Affiliations

HCV 6a was expanding and became the predominant subtype among blood donors between 2004 and 2019 in Guangdong, China

Rongsong Du et al. Virol Sin. 2022 Oct.

Abstract

  1. •

    Currently, HCV 6a has replaced 1b as the most prevalent subtype in blood donors in Guangdong.

  2. •

    HCV 6a was the predominant subtype in males and older donors, while 1b predominated in females and younger donors.

  3. •

    HCV 6a may expand from Guangdong to other districts of China, and is worthy of attention.

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Figures

Fig. 1
Fig. 1
Distribution and time trends of different HCV subtypes among blood donors between 2004 and 2019 in Guangdong, China. A Circular form of the phylogenetic tree based on all 743 E1 sequences. Different subtypes are shown in different colors, as indicated on the tree. The pie chart inside the tree indicate the percentages occupied by different HCV subtypes. B Characteristics of HCV infected blood donors in Guangzhou from 2004 to 2019. C Temporal distribution of HCV genotypes in individuals of Guangdong and non-Guangdong origin over the four study periods (2004–2019). Each study period consisted of four years, and Chi-square trend test (linear-by-linear association) was used to calculate the P-value for 1b, 6a, and others (including 1a, 4a, 6e, and 6n), respectively. D Temporal distribution of HCV genotypes in male and female blood donors. E Temporal distribution of HCV genotypes in the younger age group (<40 years) and older age group (≥40 years).
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References

    1. Du G., Li X., Musa T.H., Ji Y., Wu B., He Y., Ni Q., Su L., Li W., Ge Y. The nationwide distribution and trends of hepatitis c virus genotypes in mainland China. J. Med. Virol. 2019;91:401–410. - PubMed
    1. Fu Y., Wang Y., Xia W., Pybus O.G., Qin W., Lu L., Nelson K. New trends of hcv infection in China revealed by genetic analysis of viral sequences determined from first-time volunteer blood donors. J. Viral Hepat. 2011;18:42–52. - PMC - PubMed
    1. Fu Y., Qin W., Cao H., Xu R., Tan Y., Lu T., Wang H., Tong W., Rong X., Li G., Yuan M., Li C., Abe K., Lu L., Chen G. Hcv 6a prevalence in guangdong province had the origin from vietnam and recent dissemination to other regions of China: phylogeographic analyses. PLoS One. 2012;7 - PMC - PubMed
    1. Fu P., Lv Y., Zhang H., Liu C., Wen X., Ma H., He T., Ke L., Wu B., Liu J., He M., Liao D., Wang J., Ness P., Liu Y., Shan H. Hepatitis c virus prevalence and incidence estimates among Chinese blood donors. Transfusion. 2019;59:2913–2921. - PubMed
    1. Lu L., Nakano T., He Y., Fu Y., Hagedorn C.H., Robertson B.H. Hepatitis c virus genotype distribution in China: predominance of closely related subtype 1b isolates and existence of new genotype 6 variants. J. Med. Virol. 2005;75:538–549. - PubMed

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