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. 2023 Mar-Apr;14(2):100582.
doi: 10.1016/j.jaim.2022.100582. Epub 2022 Jul 13.

Methanolic fruit extract of Myrica nagi protects the hypothalamus and attenuates inflammation associated with gold thioglucose- and high-fat diet-induced obesity via various adipokines

Yash Prashar  1 , Nilesh J Patel  2
Affiliations

Methanolic fruit extract of Myrica nagi protects the hypothalamus and attenuates inflammation associated with gold thioglucose- and high-fat diet-induced obesity via various adipokines

Yash Prashar et al. J Ayurveda Integr Med. 2023 Mar-Apr.

Abstract

Background: Myrica nagi is popular in unani and ayurveda. Chemical constituents like myricetin isolated from its fruit has been shown to exert beneficial effects against cardiovascular disease, cancer, inflammatory conditions, and metabolic disorders.

Objectives: This study aimed to elucidate the anti-obesity effect of the methanolic extract of M. nagi (MEMN) using in vivo animal models of obesity induced by gold thioglucose or a high-fat diet.

Materials and methods: The obese mice were treated or untreated with MEMN for 8 weeks. Thereafter, feed intake, Lee index, and body mass index (BMI); biochemical parameters such as lipid profile, liver enzymes and specific biomarkers of obesity, including insulin, leptin, adiponectin, free fatty acids (FFA), monocyte chemoattractant protein (MCP)-1, and resistin, were recorded. The weight and histopathology of organs and fat tissue were examined to validate the effectiveness of the extract.

Results: MEMN administration at various doses significantly reduced the induced weight gain, feed intake, BMI, and Lee index. Adipose tissue decreased as the MEMN dose increased. MEMN attenuated liver enzyme activity, decreased lipid, leptin, MCP-1, resistin, and FFA levels, and increased adiponectin levels. It also increased protection of liver cells and decreased accumulation of mesenteric fat.

Conclusions: MEMN supplementation decreased weight and improved obesity serum/plasma lipid biomarker, insulin, leptin, adiponectin, MCP-1, and resistin levels. The weight-reducing activity of MEMN may be mediated by decreased gastrointestinal fat absorption and modulation of inflammation associated signaling pathways, leading to reduced adipose inflammation associated with energy expenditure.

Keywords: Gold thioglucose; High-fat diet; Methanolic extract; Myrica nagi; Obesity.

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Figures

Fig. 1
Fig. 1
Histopathological changes in mouse liver of a high-fat diet (HFD) model 100× Magnification.
Fig. 2
Fig. 2
Histopathological changes in mouse mesenteric fat in a high-fat diet (HFD) model 100× magnification.
Fig. 3
Fig. 3
Histopathological analysis of adipose tissue in a gold thioglucose (GTG) model 100x.
Fig. 4
Fig. 4
Histopathological analysis of liver tissue in a gold thioglucose (GTG) model. 100x.
Fig. 5
Fig. 5
Histopathological evaluation of brain tissue in a gold thioglucose (GTG) model 100x.
See this image and copyright information in PMC

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