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Comment
. 2022 Jul 16;7(1):238.
doi: 10.1038/s41392-022-01108-6.

ESCRT machinery: role of membrane repair mechanisms in escaping cell death

Lisa Gregor #  1 , Sophia Stock #  1   2   3 , Sebastian Kobold  4   5   6
Affiliations
Comment

ESCRT machinery: role of membrane repair mechanisms in escaping cell death

Lisa Gregor et al. Signal Transduct Target Ther. .
No abstract available

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Conflict of interest statement

L.G. and S.S. declare no competing interests. S.K. has received honoraria from TCR2 Inc., Novartis, BMS and GSK. S.K. is an inventor of several patents in the field of immuno-oncology. S.K. received license fees from TCR2 Inc and Carina Biotech. S.K. received research support from TCR2 Inc., Tabby Therapeutics and Arcus Bioscience for work unrelated to the manuscript.

Figures

Fig. 1
Fig. 1
a Schematic illustration of secretion of the pore-forming toxin perforin and the following delivery of apoptosis-inducing serine proteases (granzymes). b Membrane repair of perforin pores by the ESCRT machinery limits granzyme entry into the cytosol, allowing target cells to better resist the cytolytic attack. c Inhibition of the ESCRT machinery in cancer cells increases their susceptibility to cytotoxic T cell-mediated killing
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References

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    1. Jimenez AJ, et al. ESCRT machinery is required for plasma membrane repair. Science. 2014;343:1247136. doi: 10.1126/science.1247136. - DOI - PubMed
    1. Scheffer LL, et al. Mechanism of Ca(2)(+)-triggered ESCRT assembly and regulation of cell membrane repair. Nat. Commun. 2014;5:5646. doi: 10.1038/ncomms6646. - DOI - PMC - PubMed

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