Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Feb;75(2):335-341.
doi: 10.1007/s13304-022-01315-4. Epub 2022 Jul 16.

Prevention and treatment of a positive proximal margin after gastrectomy for cardia cancer

Eider Talavera-Urquijo  1 , Andrew R Davies  2 , Bas P L Wijnhoven  3
Affiliations
Review

Prevention and treatment of a positive proximal margin after gastrectomy for cardia cancer

Eider Talavera-Urquijo et al. Updates Surg. 2023 Feb.

Abstract

A tumour-positive proximal margin (PPM) after extended gastrectomy for oesophagogastric junction (OGJ) adenocarcinoma is observed in approximately 2-20% of patients. Although a PPM is an unfavourable prognostic factor, the clinical relevance remains unclear as it may reflect poor tumour biology. This narrative review analyses the most relevant literature on PPM after gastrectomy for OGJ cancers. Awareness of the risk factors and possible measures that can be taken to reduce the risk of PPM are important. In patients with a PPM, surgical and non-surgical treatments are available but the effectiveness remains unclear.

Keywords: Cardia cancer; Extended total gastrectomy; Junctional adenocarcinoma; Positive resection margin; R1.

PubMed Disclaimer

Conflict of interest statement

The authors have no relevant financial or non-financial interests to disclose.

Similar articles

See all similar articles

Cited by

References

    1. Han WH, Eom BW, Yoon HM, Reim D, Kim YW, Kim MS, et al. The optimal extent of lymph node dissection in gastroesophageal junctional cancer: retrospective case control study. BMC Cancer. 2019;19:719. doi: 10.1186/s12885-019-5922-8. - DOI - PMC - PubMed
    1. Bartel M, Brahmbhatt B, Bhurwal A. Incidence of gastroesophageal junction cancer continues to rise: analysis of surveillance, epidemiology, and end results (SEER) database. J Clin Oncol. 2019;37(4 suppl):40–40. doi: 10.1200/JCO.2019.37.4_suppl.40. - DOI
    1. Rüdiger Siewert J, Feith M, Werner M, Stein HJ. Adenocarcinoma of the esophagogastric junction: results of surgical therapy based on anatomical/topographic classification in 1,002 consecutive patients. Ann Surg. 2000;232(3):353–361. doi: 10.1097/00000658-200009000-00007. - DOI - PMC - PubMed
    1. Suh YS, Na D, Lee JS, et al. Comprehensive molecular characterization of adenocarcinoma of the gastroesophageal junction between esophageal and gastric adenocarcinomas. Ann Surg. 2020 doi: 10.1097/SLA.0000000000004303. - DOI - PubMed
    1. Lin D, Khan U, Goetze TO, Reizine N, Goodman KA, Shah MA, et al. Gastroesophageal junction adenocarcinoma: is there an optimal management? Am Soc Clin Oncol Educ Book. 2019;39:e88–e95. doi: 10.1200/EDBK_236827. - DOI - PubMed

Supplementary concepts