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. 2022 Jun 10;9(5):652-658.
doi: 10.1002/mdc3.13487. eCollection 2022 Jul.

Periodic Limb Movements while Awake (PLMA) as a Manifestation of Wearing-Off in Parkinson's Disease: A Case Series and Review of the Literature

Sohaila Alshimemeri  1   2 , Daniel G Di Luca  1 , Diana A Olszewska  1 , Eoin Mulroy  3 , Kailash P Bhatia  3 , Susan H Fox  1 , Anthony E Lang  1
Affiliations

Periodic Limb Movements while Awake (PLMA) as a Manifestation of Wearing-Off in Parkinson's Disease: A Case Series and Review of the Literature

Sohaila Alshimemeri et al. Mov Disord Clin Pract. .

Abstract

Background: Periodic limb movements while awake (PLMA) are similar to Periodic limb movements in sleep (PLMS) but occurring during wakefulness and seen in association with restless leg syndrome (RLS).

Objectives: To describe PLMA as a wearing-off phenomenon in Parkinson's Disease (PD).

Methods: We describe four individuals with PD and PLMS, who had associated similar periodic and stereotypic lower extremity movements during wakefulness, thought to be secondary to PLMA, and were highly responsive to dopaminergic treatment.

Results: Despite the prevalence of RLS and PLMS in individuals with PD, the presence of similar movements during wakefulness has not been well characterized. The lack of a specific diagnostic criteria poses a significant diagnostic challenge.

Conclusions: We describe, for the first time to our knowledge, PLMA as a wearing-off phenomenon in PD. This entity could be classified in the spectrum of "low-dose dyskinesia," as we found that it was highly responsive to dopaminergic treatment.

Keywords: Low‐dose dyskinesia; Parkinson's disease; Periodic limb movements while awake; Wearing off.

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Conflict of interest statement

We did not receive specific funding for this work. We declare that there are no conflicts of interest relevant to this work.

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References

    1. American Academy of Sleep Medicine . International classification of sleep disorders. Diagn Coding Manual 2005;51–55.
    1. Allen RP, Picchietti DL, Garcia‐Borreguero D, et al. Restless legs syndrome/Willis–Ekbom disease diagnostic criteria: Updated international restless legs syndrome study group (IRLSSG) consensus criteria–history, rationale, description, and significance. Sleep Med 2014;15:860–873. - PubMed
    1. Allen RP, Picchietti D, Hening WA, Trenkwalder C, Walters AS, Montplaisi J. Restless legs syndrome: Diagnostic criteria, special considerations, and epidemiology: A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health. Sleep Med 2003;4:101–119. - PubMed
    1. Michaud M, Paquet J, Lavigne G, Desautels A, Montplaisir J. Sleep laboratory diagnosis of restless legs syndrome. Eur Neurol 2002;48:108–113. - PubMed
    1. Ondo WG, Vuong KD, Jankovic J. Exploring the relationship between Parkinson disease and restless legs syndrome. Arch Neurol 2002;59:421–424. - PubMed

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