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Editorial
. 2022 Jun 30:13:960829.
doi: 10.3389/fimmu.2022.960829. eCollection 2022.

Editorial: The Role of Microorganisms in Multiple Myeloma

Maria Linares  1   2   3 , Sylvie Hermouet  4   5
Affiliations
Editorial

Editorial: The Role of Microorganisms in Multiple Myeloma

Maria Linares et al. Front Immunol. .
No abstract available

Keywords: MGUS; autoimmunity; chronic antigen stimulation; infection; microbiota; microorganisms; myeloma.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Micro-organisms as initiating events in the pathogenesis of MGUS and MM, and interest for treatment. MM is always preceded by a MGUS stage, considered benign since only a fraction of MGUS eventually progress toward to overt MM. Although MGUS is most often asymptomatic, patients may present with renal, neurological or skin symptoms of various severity (for instance, monoclonal gammopathies of renal significance (MGRS)) (–8). Associations between MGUS and autoimmune disorders, infection and recently, gut microbiota, are established (, , , , –22). Importantly, several groups demonstrated that monoclonal Ig from MGUS and MM patients specifically target either a self-antigen (including myelin-associated glycoprotein (MAG), glucosylsphingosine (GlcSph, in 13-15% MGUS/MM cases), other gangliosides, different membrane components) or an antigen from an infectious pathogen (including HCV, HBV, HIV, EBV, other Herpesviruses, Helicobacter pylori, or Enteroviruses, in 60% MGUS and 33% MM). That subsets of monoclonal Igs target antigens of the microbiota remains to be proven. Knowing the target of a patient’s monoclonal Ig is essential, for it allows to identify the likely initiating event of the disease, and to propose target antigen reduction therapy to patients. The efficacy of this new therapeutic approach is proven for GlcSph-, HIV- and HCV-initiated monoclonal gammopathies (, , Rodríguez–García et al.), and deserves to be tested for MGUS and MM initiated by other treatable microorganisms.
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  • Editorial on the Research Topic The Role of Microorganisms in Multiple Myeloma

References

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