Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2021 Jun 5;2(3):562-564.
doi: 10.1002/jha2.247. eCollection 2021 Aug.

Successful treatment of an EBV-positive HIV-associated polymorphic B-cell lymphoproliferative disorder by rituximab monotherapy

Mohamad Sabbah  1 , Sylvain Choquet  1 , Agathe Maillon  2 , Clotilde Bravetti  2 , Marine Baron  1 , Frédéric Charlotte  3 , Damien Roos-Weil  1
Affiliations
Case Reports

Successful treatment of an EBV-positive HIV-associated polymorphic B-cell lymphoproliferative disorder by rituximab monotherapy

Mohamad Sabbah et al. EJHaem. .
No abstract available

Keywords: HIV; polymorphic B‐cell lymphoproliferative disorder; rituximab.

PubMed Disclaimer

Conflict of interest statement

The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research reported.Mohamad Sabbah, Sylvain Choquet, Agathe Maillon, Clotilde Bravetti, Marine Baron, Frédéric Charlotte, and Damien Roos‐Weil performed, designed the research study, analyzed the data, and wrote the paper.

Figures

FIGURE 1
FIGURE 1
(A) Rectal mass biopsy showed (a) polymorphous infiltrate made up of variable size lymphocytes mixed with plasma cells (H&E staining), (b) CD20‐positive lymphocytes of variable size (CD20 immunostaining), (c) few EBV‐positive cells (EBV in situ hybridization, EBER probe), and polytypic expression of light chain immunoglobulin by plasma cells ((d) kappa and (e) lambda light chain immunostaining). (B) B‐cell clonality profile (Genemapper software): polyclonal aspect at the locus of immunoglobulin heavy chain gene. (C) Computed tomography (CT)‐scan images of rectal mass (indicated by black arrow) before (up) and after (down) rituximab monotherapy. No PET‐scan was available for this patient due to the lack of social security
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Dharnidharka VR, Webster AC, Martinez OM, Preiksaitis JK, Leblond V, Choquet S. Post‐transplant lymphoproliferative disorders. Nat Rev Dis Primers. 2016;2:15088. - PubMed
    1. Nador RG, Chadburn A, Gundappa G, Cesarman E, Said JW, Knowles DM. Human immunodeficiency virus (HIV)‐associated polymorphic lymphoproliferative disorders. Am J Surg Pathol. 2003;27:293–302. - PubMed
    1. Trappe RU, Dierickx D, Zimmermann H. Response to rituximab induction is a predictive marker in B‐cell post‐transplant lymphoproliferative disorder and allows successful stratification into rituximab or R‐CHOP consolidation in an international, prospective, multicenter phase II trial. J Clin Oncol. 2017;35:536–543. - PubMed
    1. Natkunam Y, Goodlad JR, Chadburn A. EBV‐positive B‐cell proliferations of varied malignant potential: 2015 SH/EAHP workshop report‐part 1. Am J Clin Pathol. 2017;147:129–152. - PMC - PubMed
    1. Buxton J, Leen C, Goodlad JR. Polymorphic lymphoid proliferations occurring in HIV‐positive patients: report of a case responding to HAART. Virchows Arch. 2012;461:93–98. - PubMed

Publication types