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Review
. 2022 Jun 13;18(10):3981-3992.
doi: 10.7150/ijbs.71491. eCollection 2022.

The role of intestinal microbiota and its metabolites in intestinal and extraintestinal organ injury induced by intestinal ischemia reperfusion injury

Fan Deng  1 , Ze-Bin Lin  1 , Qi-Shun Sun  1 , Yue Min  1 , Yue Zhang  1 , Yu Chen  1 , Wen-Ting Chen  1 , Jing-Juan Hu  1 , Ke-Xuan Liu  1
Affiliations
Review

The role of intestinal microbiota and its metabolites in intestinal and extraintestinal organ injury induced by intestinal ischemia reperfusion injury

Fan Deng et al. Int J Biol Sci. .

Abstract

Intestinal ischemia/reperfusion (I/R) is a common pathophysiological process in clinical severe patients, and the effect of intestinal I/R injury on the patient's systemic pathophysiological state is far greater than that of primary intestinal injury. In recent years, more and more evidence has shown that intestinal microbiota and its metabolites play an important role in the occurrence, development, diagnosis and treatment of intestinal I/R injury. Intestinal microbiota is regulated by host genes, immune response, diet, drugs and other factors. The metabolism and immune potential of intestinal microbiota determine its important significance in host health and diseases. Therefore, targeting the intestinal microbiota and its metabolites may be an effective therapy for the treatment of intestinal I/R injury and intestinal I/R-induced extraintestinal organ injury. This review focuses on the role of intestinal microbiota and its metabolites in intestinal I/R injury and intestinal I/R-induced extraintestinal organ injury, and summarizes the latest progress in regulating intestinal microbiota to treat intestinal I/R injury and intestinal I/R-induced extraintestinal organ injury.

Keywords: Intestinal ischemia reperfusion; Intestinal microbiota; Metabolites; extraintestinal organ injury.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

Figures

Figure 1
Figure 1
Intestinal I/R injury. I/R, ischemia reperfusion; ASA, American Society of Anesthesiologists; TLR, Toll-like receptors; MYD88, Myeloid differentiation factor 88; ROS, Reactive oxygen species; TNF, tumor necrosis factor.
Figure 2
Figure 2
The changes of metabolites in intestinal I/R.
See this image and copyright information in PMC

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