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Meta-Analysis
. 2022 Jun 30:10:890652.
doi: 10.3389/fpubh.2022.890652. eCollection 2022.

The Impact of Frailty on Adverse Outcomes in Geriatric Hip Fracture Patients: A Systematic Review and Meta-Analysis

Yanhong Song  1 , Ziyi Wu  1 , Huihui Huo  2 , Ping Zhao  1
Affiliations
Meta-Analysis

The Impact of Frailty on Adverse Outcomes in Geriatric Hip Fracture Patients: A Systematic Review and Meta-Analysis

Yanhong Song et al. Front Public Health. .

Abstract

Objective: With an aging population and advances in medicine, more research focuses on health and longevity in geriatric adults. Recently, frailty has gradually emerged to assess physical conditions. Frailty can be generally described as a multi-dimensional situation of increased vulnerabilities to both endogenous and exogenous stressors. The objective of the review was to evaluate the predictive value of frailty on adverse outcomes in geriatric hip fracture patients.

Materials and methods: We searched PubMed, Embase, Web of Science, and the Cochrane library for relevant literature about the connection between frailty and poor outcomes in hip fracture elders.

Results: Eleven studies involving a total of 45,979 participants were selected in our study. Our results indicated that frailty could significantly predict postoperative and in-patient complications (OR, 1.46; 95% CI, 1.13-1.90; I2 = 77.4%). Frail elders had higher risk of inpatient mortality (OR, 1.68; 95% CI, 1.26-2.25; I2 = 0.0%), 6-month mortality (OR, 1.46; 95% CI, 1.25-1.72; I2 = 0.0%) and ≥1-year mortality (OR, 2.24; 95% CI, 1.66-3.04; I2 = 91.3%). Furthermore, the risk of prolonged hospital stays was 1.15 times more likely in frail patients (95% CI, 1.03-1.28; I2 = 14.8%).

Conclusion: Frailty can predict adverse outcomes effectively in geriatric hip fracture patients.

Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/#recordDetails.

Keywords: adverse outcomes; elders; frailty; hip fracture; meta-analysis.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flow diagram of the study selection process.
Figure 2
Figure 2
Subgroup analysis for the studies reporting ≥ 1-year mortality.
Figure 3
Figure 3
Subgroup analysis for the studies reporting post-operative and in-patient complications.
See this image and copyright information in PMC

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References

    1. He W, Goodkind D, Kowal P. An Aging World: 2015. International Popular Reports; (2016).
    1. Partridge JS, Harari D, Dhesi JK. Frailty in the older surgical patient: a review. Age Ageing. (2012) 41:142–7. 10.1093/ageing/afr182 - DOI - PubMed
    1. Greco EA, Pietschmann P, Migliaccio S. Osteoporosis and sarcopenia increase frailty syndrome in the elderly. Front Endocrinol. (2019) 10:255. 10.3389/fendo.2019.00255 - DOI - PMC - PubMed
    1. Rolland Y, Abellan van Kan G, Bénétos A, Blain H, Bonnefoy M, Chassagne P, et al. . Frailty, osteoporosis and hip fracture: causes, consequences and therapeutic perspectives. J Nutr Health Aging. (2008) 12:335–46. 10.1007/BF02982665 - DOI - PubMed
    1. Fhon JR, Rodrigues RA, Neira WF, Huayta VM, Robazzi ML. Fall and its association with the frailty syndrome in the elderly: systematic review with meta-analysis. Rev Esc Enferm USP. (2016) 50:1005–13. 10.1590/s0080-623420160000700018 - DOI - PubMed