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. 2022 Jul 1:10:936552.
doi: 10.3389/fpubh.2022.936552. eCollection 2022.

Physical Activity Reduces the Effect of High Body Mass Index on Kidney Stones in Diabetes Participants From the 2007-2018 NHANES Cycles: A Cross-Sectional Study

Weipu Mao  1   2 , Lei Zhang  2 , Si Sun  2 , Jianping Wu  2 , Xiangyu Zou  3 , Guangyuan Zhang  2 , Ming Chen  2
Affiliations

Physical Activity Reduces the Effect of High Body Mass Index on Kidney Stones in Diabetes Participants From the 2007-2018 NHANES Cycles: A Cross-Sectional Study

Weipu Mao et al. Front Public Health. .

Abstract

Background: Body mass index (BMI) is a vital risk factor for kidney stones, but physical activity may reduce the incidence of kidney stones. However, it remains unknown whether physical activity reduces the effect of high BMI on kidney stones in diabetes participants.

Methods: We included clinical information from 4,008 adult participants with diabetes from the National Health and Nutrition Examination Survey (NHANES) database from 2007 to 2018. Univariate and multivariate logistic regression analyses were used to analyze the relationship between BMI and kidney stones, as well as the risk of BMI and kidney stones in different physical activity subgroups.

Results: A total of 4,008 diabetic participants were included in this study, of whom 652 (16.3%) self-reported a history of kidney stones. Logistic regression analysis showed a positive association between BMI and kidney stones. After adjusting for other confounders, the adjusted ORs for the risk of kidney stones was 1.514 (95% CI, 1.134-2.022, p = 0.005) for participants with BMI ≥30 kg/m2 among all participants; the risk of kidney stones was elevated (OR = 1.572, 95% CI, 1.134-2.022, p = 0.005) in group without physical activity, and a reduced risk (OR = 1.421, 95% CI, 0.847-2.382, p = 0.183) in the group with physical activity. Furthermore, similar results were found in most subgroups.

Conclusion: Our study suggests that high BMI is a risk factor for diabetes kidney stone participants and that physical activity may moderate this relationship to some extent.

Keywords: NHANES database; body mass index; diabetes; kidney stones; physical activity.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Schematic overview for patient identification.
Figure 2
Figure 2
Prevalence of kidney stones in different BMI groups among different physical activity groups.
Figure 3
Figure 3
The dose–response analysis of kidney stones with BMI by physical activity type. OR, Odds ratio; CI, Confidence interval.
See this image and copyright information in PMC

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References

    1. Singh P, Harris PC, Sas DJ, Lieske JC. The genetics of kidney stone disease and nephrocalcinosis. Nat Rev Nephrol. (2022) 18:224–40. 10.1038/s41581-021-00513-4 - DOI - PubMed
    1. Zisman AL, Coe FL, Cohen AJ, Riedinger CB, Worcester EM. Racial differences in risk factors for kidney stone formation. Clin J Am Soc Nephrol. (2020) 15:1166–73. 10.2215/CJN.12671019 - DOI - PMC - PubMed
    1. Denburg MR, Koepsell K, Lee JJ, Gerber J, Bittinger K, Tasian GE. Perturbations of the gut microbiome and metabolome in children with calcium oxalate kidney stone disease. J Am Soc Nephrol. (2020) 31:1358–69. 10.1681/ASN.2019101131 - DOI - PMC - PubMed
    1. Mao W, Hu Q, Chen S, Chen Y, Luo M, Zhang Z, et al. . Polyfluoroalkyl chemicals and the risk of kidney stones in US adults: a population-based study. Ecotoxicol Environ Saf. (2021) 208:111497. 10.1016/j.ecoenv.2020.111497 - DOI - PubMed
    1. Islam AK, Holt S, Reisch J, Nwariaku F, Antonelli J, Maalouf NM. What predicts recurrent kidney stone after parathyroidectomy in patients with primary hyperparathyroidism? J Am Coll Surg. (2020) 231:74–82. 10.1016/j.jamcollsurg.2020.04.015 - DOI - PubMed

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