Shelter from the storm: Acetaminophen (paracetamol) in pregnancy, urogenital malformations, and childhood neurodevelopment

doi:10.1177/1753495X221080883

Editorial

. 2022 Jun;15(2):77-78.

doi: 10.1177/1753495X221080883. Epub 2022 Feb 22.

Shelter from the storm: Acetaminophen (paracetamol) in pregnancy, urogenital malformations, and childhood neurodevelopment

Per Damkier^{1

2

3}, Kenneth Hodson^{4

5}

Affiliations

¹ Department of Clinical Pharmacology, Odense University Hospital, Odense, Denmark.
² Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
³ Department of Public Health, University of Southern Denmark, Odense, Denmark.
⁴ Newcastle Upon Tyne NHS Foundation Trust, Royal, Victoria Infirmary, Newcastle upon Tyne, UK.
⁵ UK Teratology Information Service, Newcastle upon Tyne, UK.

PMID: 35845231
PMCID: PMC9277736
DOI: 10.1177/1753495X221080883

Editorial

Shelter from the storm: Acetaminophen (paracetamol) in pregnancy, urogenital malformations, and childhood neurodevelopment

Per Damkier et al. Obstet Med. 2022 Jun.

. 2022 Jun;15(2):77-78.

doi: 10.1177/1753495X221080883. Epub 2022 Feb 22.

Authors

Per Damkier^{1

2

3}, Kenneth Hodson^{4

5}

Affiliations

¹ Department of Clinical Pharmacology, Odense University Hospital, Odense, Denmark.
² Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
³ Department of Public Health, University of Southern Denmark, Odense, Denmark.
⁴ Newcastle Upon Tyne NHS Foundation Trust, Royal, Victoria Infirmary, Newcastle upon Tyne, UK.
⁵ UK Teratology Information Service, Newcastle upon Tyne, UK.

PMID: 35845231
PMCID: PMC9277736
DOI: 10.1177/1753495X221080883

No abstract available

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Conflict of interest statement

Declaration of conflicting interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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Acetaminophen in Pregnancy: A Population-Level Drug-Utilization Study of Prescription-Based Acetaminophen Use Among Pregnant Women in Denmark From 2001 to 2023.
Pflugfelder S, Gram EB, Damkier P. Pflugfelder S, et al. Basic Clin Pharmacol Toxicol. 2025 Jun;136(6):e70048. doi: 10.1111/bcpt.70048. Basic Clin Pharmacol Toxicol. 2025. PMID: 40313013 Free PMC article.
Core Data Elements for Pregnancy Pharmacovigilance Studies Using Primary Source Data Collection Methods: Recommendations from the IMI ConcePTION Project.
Richardson JL, Moore A, Bromley RL, Stellfeld M, Geissbühler Y, Bluett-Duncan M, Winterfeld U, Favre G, Alexe A, Oliver AM, van Rijt-Weetink YRJ, Hodson KK, Rezaallah B, van Puijenbroek EP, Lewis DJ, Yates LM. Richardson JL, et al. Drug Saf. 2023 May;46(5):479-491. doi: 10.1007/s40264-023-01291-7. Epub 2023 Mar 28. Drug Saf. 2023. PMID: 36976447 Free PMC article. Review.

References

1. Olsen J, Liew Z. Fetal programming of mental health by acetaminophen? Response to the SMFM statement: prenatal acetaminophen use and ADHD. Expert Opin Drug Saf 2017 Dec; 16: 1395–1398. - PubMed
1. Damkier P, Pottegård A, dePont Christensen Ret al. et al. Annotations and reflections: pregnancy and paracetamol: methodological considerations on the study of associations between in utero exposure to drugs and childhood neurodevelopment. Basic Clin Pharmacol Toxicol 2015; 116: 2–5. - PubMed
1. Kristensen DM, Hass U, Lesné L, et al. Intrauterine exposure to mild analgesics is a risk factor for development of male reproductive disorders in humans and rat. Hum Reprod 2011; 26: 235–244. - PubMed
1. Lind DV, Main KM, Kyhl HB, et al. Maternal use of mild analgesics during pregnancy associated with reduced anogenital distance in sons: a cohort study of 1027 mother-pairs. Hum Reprod 2017; 32: 223–231. - PubMed
1. Bauer AZ, Swan SH, Kriebel D, et al. Paracetamol use during pregnancy — a call for precautionary action. Nat Rev Endocrinol 2021; 12: 757– 766. - PMC - PubMed

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[1] Olsen J, Liew Z. Fetal programming of mental health by acetaminophen? Response to the SMFM statement: prenatal acetaminophen use and ADHD. Expert Opin Drug Saf 2017 Dec; 16: 1395–1398. - PubMed

[2] Olsen J, Liew Z. Fetal programming of mental health by acetaminophen? Response to the SMFM statement: prenatal acetaminophen use and ADHD. Expert Opin Drug Saf 2017 Dec; 16: 1395–1398. - PubMed

[3] Damkier P, Pottegård A, dePont Christensen Ret al. et al. Annotations and reflections: pregnancy and paracetamol: methodological considerations on the study of associations between in utero exposure to drugs and childhood neurodevelopment. Basic Clin Pharmacol Toxicol 2015; 116: 2–5. - PubMed

[4] Damkier P, Pottegård A, dePont Christensen Ret al. et al. Annotations and reflections: pregnancy and paracetamol: methodological considerations on the study of associations between in utero exposure to drugs and childhood neurodevelopment. Basic Clin Pharmacol Toxicol 2015; 116: 2–5. - PubMed

[5] Kristensen DM, Hass U, Lesné L, et al. Intrauterine exposure to mild analgesics is a risk factor for development of male reproductive disorders in humans and rat. Hum Reprod 2011; 26: 235–244. - PubMed

[6] Kristensen DM, Hass U, Lesné L, et al. Intrauterine exposure to mild analgesics is a risk factor for development of male reproductive disorders in humans and rat. Hum Reprod 2011; 26: 235–244. - PubMed

[7] Lind DV, Main KM, Kyhl HB, et al. Maternal use of mild analgesics during pregnancy associated with reduced anogenital distance in sons: a cohort study of 1027 mother-pairs. Hum Reprod 2017; 32: 223–231. - PubMed

[8] Lind DV, Main KM, Kyhl HB, et al. Maternal use of mild analgesics during pregnancy associated with reduced anogenital distance in sons: a cohort study of 1027 mother-pairs. Hum Reprod 2017; 32: 223–231. - PubMed

[9] Bauer AZ, Swan SH, Kriebel D, et al. Paracetamol use during pregnancy — a call for precautionary action. Nat Rev Endocrinol 2021; 12: 757– 766. - PMC - PubMed

[10] Bauer AZ, Swan SH, Kriebel D, et al. Paracetamol use during pregnancy — a call for precautionary action. Nat Rev Endocrinol 2021; 12: 757– 766. - PMC - PubMed

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Shelter from the storm: Acetaminophen (paracetamol) in pregnancy, urogenital malformations, and childhood neurodevelopment

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Shelter from the storm: Acetaminophen (paracetamol) in pregnancy, urogenital malformations, and childhood neurodevelopment

Authors

Affiliations

Conflict of interest statement

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