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. 2022 Jun 29:13:950885.
doi: 10.3389/fpsyt.2022.950885. eCollection 2022.

Vortioxetine Modulates the Regional Signal in First-Episode Drug-Free Major Depressive Disorder at Rest

Shihong Xiong  1 , Wei Li  2 , Yang Zhou  3 , Hongwei Ren  4 , Guorong Lin  3 , Sheng Zhang  5 , Xi Xiang  6
Affiliations

Vortioxetine Modulates the Regional Signal in First-Episode Drug-Free Major Depressive Disorder at Rest

Shihong Xiong et al. Front Psychiatry. .

Abstract

Background: Previous studies on brain functional alterations associated with antidepressants for major depressive disorder (MDD) have produced conflicting results because they involved short treatment periods and a variety of compounds.

Methods: Resting-state functional magnetic resonance imaging scans were obtained from 25 first-episode drug-free patients with MDD and 25 healthy controls. The patients, who were treated with vortioxetine for 8 weeks, were scanned at two-time points (baseline and week 8 of treatment). The amplitude of low-frequency fluctuation (ALFF) in the imaging data was used to analyze local brain signal alterations associated with antidepressant treatment.

Results: Compared with the controls, the patients at baseline showed decreased ALFF values in the right inferior temporal gyrus and increased ALFF values in the left inferior cerebellum, right cingulate gyrus and postcentral gyrus. After 8 weeks of vortioxetine treatment, patients showed increased ALFF values in the bilateral cingulate gyrus, middle temporal gyrus, medial superior frontal gyrus, and inferior cerebellum.

Conclusion: This study provided evidence that vortioxetine modulates brain signals in MDD sufferers. These findings contribute to the understanding of how antidepressants effect brain function.

Keywords: MRI; amplitude of low-frequency fluctuation; major depressive disorder; temporal lobe; vortioxetine.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The reviewer XJ declared a shared affiliation with the author SZ at the time of review.

Figures

FIGURE 1
FIGURE 1
Alterations in ALFF among patients (at baseline, after treatment) and controls. Red indicates the brain area where ALFF values were significantly increased, and the color depth indicates the differences between the three groups.
FIGURE 2
FIGURE 2
Comparison of patients and controls at baseline. Blue indicates the brain area where ALFF values were significantly reduced. Red indicates the brain area where ALFF values were significantly increased, and the color depth indicates the difference between the two groups.
FIGURE 3
FIGURE 3
Comparison of patients and controls after treatment. Red indicates the brain area where ALFF values were significantly increased, and the color depth indicates the difference between the two groups.
See this image and copyright information in PMC

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