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. 2022;27(5):467-469.
doi: 10.5863/1551-6776-27.5.467. Epub 2022 Jul 6.

If At First You Don't Succeed, Trikafta Again

India Loyd  1 , Nicole Papac  2 , Jason Hirshburg  2 , Jarad Levin  2 , Jennifer Dannelley  3 , Janislynn Dorris  3 , Jason Stratton  1   2   3 , Nighat Mehdi  3
Affiliations

If At First You Don't Succeed, Trikafta Again

India Loyd et al. J Pediatr Pharmacol Ther. 2022.

Abstract

Adverse reactions, including severe cutaneous reactions, to cystic fibrosis transmembrane conductance regulator (CFTR) modulators have been described in the literature. Herein we present a drug eruption in response to elexacaftor/tezcaftor/ivacaftor (brand name, Trikafta) in a 7-year-old male with cystic fibrosis, followed by desensitization and successful continuation. A review of the literature outlining similar cases is provided. Attempting to mitigate and manage drug reactions to CFTR modulators is essential because they represent vital and irreplaceable therapies for individuals with cystic fibrosis (CF).

Keywords: CFTR modulator; cystic fibrosis; desensitizat urticaria; elexacaftor; ivacaftor; tezacaftor.

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Conflict of interest statement

Disclosures. The authors declare no conflicts or financial interest in any product or service mentioned in the manuscript. The authors had full access to all patient information in this report and take responsibility for the integrity and accuracy of the report.

Figures

Image.
Image.
Urticarial drug rash in young male.
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