Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Jul 1:15:885701.
doi: 10.3389/fnmol.2022.885701. eCollection 2022.

A Scientometric Visualization Analysis for Molecular Mechanisms of Substance Abuse and Its Neurotoxicity From 1997 to 2021

Aijia Zhang  1 , Zilong Liu  1 , Man Liang  1
Affiliations

A Scientometric Visualization Analysis for Molecular Mechanisms of Substance Abuse and Its Neurotoxicity From 1997 to 2021

Aijia Zhang et al. Front Mol Neurosci. .

Abstract

Substance abuse has become a global problem due to drug-induced addiction and neurotoxicity, which causes a huge physical, social, and financial burden. Various kinds of drugs can hijack the users'/abusers' behavior and associated neurocircuitry. To summarize recent scientific advances on drug abuse, we reviewed relevant publications to analyze research progress and such trends through bibliometric ways. Based on retrieval strategies, a total of 681 scientific records published from 1997 to 2021 were screened and included in the Web of Science (WoS) database. Further scientometric analysis revealed that annual publication output increased across this period, with the United States of America (USA) contributing a significant number of reasons. Research has focused on neurotransmitter, oxidative stress, mitochondrial system injury, and other neurotoxic mechanisms. Neuroimmune, neurotoxic targets, and new psychoactive substances have been hot topics in recent years, which deserve continued research in the future. Specific research on molecular mechanisms has progressed across this period, with an emphasis on the root cause of toxicity and molecular targets for therapy. Moreover, collaborations of international multi-disciplinary research teams have been efficient and need to be encouraged for addiction research and the development of appropriate therapeutic processes.

Keywords: molecular mechanism; neurotoxicity; scientometric analysis; substance abuse; visualization.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
The flowchart of methodology.
FIGURE 2
FIGURE 2
Annual number and accumulated number of articles on neurotoxicity of substance abuse, and number of publications on molecular mechanisms from 1997 to 2021.
FIGURE 3
FIGURE 3
Cooperation between contributed countries.
FIGURE 4
FIGURE 4
Network of keywords co-occurrence. The circle size and the link illustrated the frequency and relevance of keywords, respectively.
FIGURE 5
FIGURE 5
Co-cited references timeline map of neurotoxicity of substance abuse. Nodes represent referenced documents. The size of nodes represents the frequencies of cited references, and the location reflects the present time. Years are arranged horizontally at the top. The clusters are performed based on the themes of co-cited references and the label of each cluster is shown at the end of the timeline.
FIGURE 6
FIGURE 6
Top 24 keywords with the strongest citation bursts. Each blue or red short line represents a year, and a red line stands for a burst detected year.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Altun B., Çok Ý. (2020). Psychoactive bath salts and neurotoxicity risk. Turk. J. Pharm. Sci. 17 235–241. 10.4274/tjps.galenos.2018.40820 - DOI - PMC - PubMed
    1. American Psychiatric Association [APA] (2013). Diagnostic and Statistical Manual of Mental Disorders (DSM-5®). Washington, DC: American Psychiatric Publishing. 10.1176/appi.books.9780890425596 - DOI
    1. Barbosa D. J., Capela J. P., Oliveira J. M., Silva R., Ferreira L. M., Siopa F., et al. (2012). Pro-oxidant effects of ecstasy and its metabolites in mouse brain synaptosomes. Br. J. Pharmacol. 165 1017–1033. 10.1111/j.1476-5381.2011.01453.x - DOI - PMC - PubMed
    1. Baumann M. H., Partilla J. S., Lehner K. R. (2013). Psychoactive “bath salts”: not so soothing. Eur. J. Pharmacol. 698 1–5. 10.1016/j.ejphar.2012.11.020 - DOI - PMC - PubMed
    1. Burrows K. B., Gudelsky G., Yamamoto B. K. (2000). Rapid and transient inhibition of mitochondrial function following methamphetamine or 3,4-methylenedioxymethamphetamine administration. Eur. J. Pharmacol. 398 11–18. 10.1016/s0014-2999(00)00264-8 - DOI - PubMed

LinkOut - more resources