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. 2022 Jul 8:2022:3569281.
doi: 10.1155/2022/3569281. eCollection 2022.

Periapical Healing following Root Canal Treatment Using Different Endodontic Sealers: A Systematic Review

Akshay Khandelwal  1 , Krishnamachari Janani  2 , KavalipurapuVenkata Teja  3 , Jerry Jose  4 , Gopi Battineni  5 , Francesco Riccitiello  6 , Alessandra Valletta  6 , Ajitha Palanivelu  4 , Gianrico Spagnuolo  6
Affiliations

Periapical Healing following Root Canal Treatment Using Different Endodontic Sealers: A Systematic Review

Akshay Khandelwal et al. Biomed Res Int. .

Abstract

The healing of the periapical tissues is crucial to the success of root canal treatment. The review studies effectively examine various endodontic root canal sealants in terms of periapical healing. This systematic review was formulated following the PRISMA 2020 guidelines and registered in the international prospective register of systematic reviews (PROSPERO) number-CRD42021239192. To find relevant articles, PubMed Central and Medline databases (until February 2022) were searched. Studies that evaluated healing following the application of different endodontic sealers were analysed. A primary outcome measure was the resolution of periapical lesions following the endodontic treatment. In vivo studies comparing radiographic treatment outcomes and articles with a minimum of 6-month follow-up were included. A total of 9 clinical trial studies that met all the inclusion criteria were included in the analysis. The overall risk of bias was high in four studies out of nine studies. Periapical lesions showed significant healing after endodontic treatment regardless of sealer type, although bioceramic and bioactive sealers had shown better results.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Search strategy framework with PRISMA 2020 guidelines.
Figure 2
Figure 2
Risk bias domain framework.
See this image and copyright information in PMC

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