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Randomized Controlled Trial
. 2022 Jul 7:2022:4020550.
doi: 10.1155/2022/4020550. eCollection 2022.

Mindfulness-Based Stress Reduction in Breast Cancer Survivors with Chronic Neuropathic Pain: A Randomized Controlled Trial

Yaadwinder Shergill  1   2   3 , Danielle B Rice  1 , Eve-Ling Khoo  1 , Virginia Jarvis  1 , Tinghua Zhang  1 , Monica Taljaard  1 , Keith G Wilson  1   4 , Heather Romanow  1 , Brittany Glynn  1 , Rebecca Small  5 , Joshua A Rash  6 , Andra Smith  7 , Lynette Monteiro  8 , Catherine Smyth  1   5   9 , Patricia A Poulin  1   4   5
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Randomized Controlled Trial

Mindfulness-Based Stress Reduction in Breast Cancer Survivors with Chronic Neuropathic Pain: A Randomized Controlled Trial

Yaadwinder Shergill et al. Pain Res Manag. .

Abstract

Objectives: The purpose of this study was to compare the effects of group-delivered mindfulness-based stress reduction as compared to a waitlist control group among breast cancer survivors living with CNP.

Methods: A randomized controlled trial design was applied, and outcomes collected included pain, emotional function, quality of life, and global impression of change.

Results: A total of 98 women were randomized and included in analyses. The sample included 49 women in the mindfulness-based stress reduction group, and 49 women in the waitlist control group. The intervention group participants (mean age 51.3 years, standard deviation = 11.4) and waitlist participants (mean age 55.1 years, standard deviation = 9.6) reported an average pain duration of approximately three years. No significant differences were found on the primary outcome of the proportions of women with reduced pain interference scores from the time of randomization to 3 months after the intervention was received. No significant changes were found among secondary outcomes.

Conclusion: Our randomized clinical trial did not find significant benefits of group-based mindfulness-based stress reduction for the management of CNP. The current study findings should be replicated and are important to consider given ongoing concerns that nonsignificant results of mindfulness-based stress reduction are often unpublished.

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Conflict of interest statement

Dr. Lynette Monteiro received stipends to facilitate the 8-week program. All the other authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Consort study flow.
Figure 2
Figure 2
Brief Pain Inventory-Interference.
Figure 3
Figure 3
Profile of Mood States.
Figure 4
Figure 4
Patient Global Impression of Change.
Figure 5
Figure 5
Patient Health Questionnaire-9.
Figure 6
Figure 6
Short-Form-12 Health Survey-physical health T-score.
Figure 7
Figure 7
Short-form-12 Health Survey-mental health T-score.
Figure 8
Figure 8
Five Facet Mindfulness Questionnaire.
Figure 9
Figure 9
Pain Catastrophizing Scale.
Figure 10
Figure 10
Neuropathic Pain Symptom Inventory.
See this image and copyright information in PMC

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