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Review
. 2022 Jun 30:13:875442.
doi: 10.3389/fendo.2022.875442. eCollection 2022.

The Role of Liquid Biopsy Analytes in Diagnosis, Treatment and Prognosis of Colorectal Cancer

JinHua He  1 , NaiTe Xi  2 , ZePing Han  1 , WenFeng Luo  1 , Jian Shen  1 , ShengBo Wang  3 , JianHao Li  4 , ZhongHui Guo  1 , HanWei Cheng  1
Affiliations
Review

The Role of Liquid Biopsy Analytes in Diagnosis, Treatment and Prognosis of Colorectal Cancer

JinHua He et al. Front Endocrinol (Lausanne). .

Abstract

Colorectal cancer (CRC) is one of the most common malignant tumors of the digestive tract worldwide and is a serious threat to human life and health. CRC occurs and develops in a multi-step, multi-stage, and multi-gene process, in which abnormal gene expression plays an important role. CRC is currently diagnosed via endoscopy combined with tissue biopsy. Compared with tissue biopsy, liquid biopsy technology has received increasingly more attention and applications in the field of molecular detection due to its non-invasive, safe, comprehensive, and real-time dynamic nature. This review article discusses the application and limitations of current liquid biopsy analytes in the diagnosis, treatment, and prognosis of CRC, as well as directions for their future development.

Keywords: circulating tumor DNA; circulating tumor cell; circulating tumor miRNA; colorectal cancer; exosomes.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Detection process and application of circulating tumor cells.
Figure 2
Figure 2
Detection process and application of cfDNA (33).
Figure 3
Figure 3
Detection process and application of ctmiRNAs.
Figure 4
Figure 4
Detection process and application of exosomes.
Figure 5
Figure 5
Detection process and application of metabolomics.
See this image and copyright information in PMC

References

    1. GBD 2017 Colorectal Cancer Collaborators . The Global, Regional,and National Burden of Colorectal Cancer and Its Attributable Risk Factors in 195 Countries and Territories, 1990-2017:a Systematic Analysis for the Global Burden of Disease Study. Lancet Gastroenterol Hepatol (2019) 4(12):913–33. doi: 10.1016/S2468-1253(19)30345-0 - DOI - PMC - PubMed
    1. Bray F, Ferlay J, Soerjomataram I, Siegel R, Torre LA, Jemal A. Global Cancer Statistics 2018: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin (2018) 68(6):94–424. doi: 10.3322/caac.21492 - DOI - PubMed
    1. Araghi M, Soerjomataram I, Jenkins M, Brierley J, Morris E, Bray F, et al. . Global Trends in Colorectal Cancer Mortality: Projections to the Year 2035. Int J Cancer (2019) 144(12):2992–3000. doi: 10.1002/ijc.32055 - DOI - PubMed
    1. Sharp L, O'Leary E, O'Ceilleachair A, Skally M, Hanly P. Financial Impact of Colorectal Cancer and Its Consequences: Associations Between Cancer-Related Financial Stress and Strain and Health-Related Quality of Life. Dis Colon Rectum (2018) 61(1):27–35. doi: 10.1097/DCR.0000000000000923 - DOI - PubMed
    1. Duineveld LA, van Asselt KM, Bemelman WA, Smits AB, Tanis PJ, van Weert HC, et al. . Symptomatic and Asymptomatic Colon Cancer Recurrence: A Multicenter Cohort Study. Ann Fam Med (2016) 14(3):215–20. doi: 10.1370/afm.1919 - DOI - PMC - PubMed

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