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. 2022 Jul 9:80:104137.
doi: 10.1016/j.amsu.2022.104137. eCollection 2022 Aug.

Comparison of Tamsulosin and Tadalafil effects in LUTS treatment considering patients' atherosclerosis risk level

Ali Tavoosian  1 , Leonardo Oliveira Reis  2 , Pavan Aluru  3 , Alireza Khajavi  4 , Seyed Mohammad Kazem Aghamir  1
Affiliations

Comparison of Tamsulosin and Tadalafil effects in LUTS treatment considering patients' atherosclerosis risk level

Ali Tavoosian et al. Ann Med Surg (Lond). .

Abstract

Introduction: To date, no study evaluates the effect of atherosclerosis risk level on the efficacy of BPH drug therapies. Therefore, the present study aimed to assess the effect of atherosclerosis risk levels on the effectiveness of Tamsulosin and Tadalafil in LUTS treatment.

Methods: The present study was a randomized clinical trial that assessed men with LUTS symptoms (at least six months). The inclusion criteria were being older than 50 years, international prostate symptom score (IPSS) ≥ 13, and maximum urinary flow rate (Qmax) between 4 and 15 ml/s. Framingham Risk Score was used to measure atherosclerosis risk. The patients were classified into four groups, including group 1: Patients with low risk and treated with Tamsulosin (0.4 mg/day), group 2: Patients with low risk and treated with Tadalafil (5 mg/day), group 3: Patients with high risk and treated with Tamsulosin (0.4 mg/day), group 4: Patients with high risk and treated with Tadalafil (5 mg/day).

Results: The study included 44 and 38 patients receiving Tamsulosin and Tadalafil, respectively. The means (SD) of the baseline age for the Tamsulosin and Tadalafil groups were equal to 60.6 (6.8) and 58.8 (6.7), respectively (p-value = 0.213). The models revealed no impact of the atherosclerosis risk level on the drugs' effects (p-values = 0.378, 0.975, 0.743 for IPSS, QMAX, and VOID, respectively).

Conclusions: The present study's findings could not show the impact of atherosclerosis risk levels on the efficiency of Tamsolusin and Tadalafil in men with LUTS.

Keywords: Benign prostatic hyperplasia; Lower urinary tract symptoms; Tadalafil; Tamsulosin; Treatment.

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Conflict of interest statement

There is no conflict of interest.

Figures

Fig. 1
Fig. 1
The response variables' trends over the measurements of baseline and weeks 4, 8, and 12.
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