Amisulpride Augmentation of Clozapine in Clozapine-Resistant Schizophrenia: A Case Series

doi:10.4212/cjhp.3178

Case Reports

. 2022 Jul 4;75(3):234-238.

doi: 10.4212/cjhp.3178. eCollection 2022 Summer.

Amisulpride Augmentation of Clozapine in Clozapine-Resistant Schizophrenia: A Case Series

Sukhpreet Poonia¹, Mazen Sharaf², Ric M Procyshyn³, Randal White⁴, Reza Rafizadeh⁵

Affiliations

¹ , BSc(Pharm), RPh, is a Clinical Pharmacist Tertiary Mental Health with Lower Mainland Pharmacy Services, Vancouver, British Columbia.
² , BSc(Pharm), ACPR, RPh, is a Clinical Pharmacist with the BC Psychosis Program, Lower Mainland Pharmacy Services, Vancouver, British Columbia.
³ , BSc(Pharm), MSc, PharmD, PhD, is a Clinical Professor in the Department of Psychiatry, The University of British Columbia, Vancouver, British Columbia.
⁴ , MD, FRCPC, is Clinical Director of the BC Psychosis Program and a Clinical Professor in the Department of Psychiatry, The University of British Columbia, Vancouver, British Columbia.
⁵ , BSc(Pharm), ACPR, BCPP, RPh, is a Clinical Pharmacy Specialist with BC Mental Health & Substance Use Services, BC Psychosis Program, Lower Mainland Pharmacy Services, Vancouver, British Columbia.

PMID: 35847467
PMCID: PMC9245404
DOI: 10.4212/cjhp.3178

Case Reports

Amisulpride Augmentation of Clozapine in Clozapine-Resistant Schizophrenia: A Case Series

Sukhpreet Poonia et al. Can J Hosp Pharm. 2022.

. 2022 Jul 4;75(3):234-238.

doi: 10.4212/cjhp.3178. eCollection 2022 Summer.

Authors

Sukhpreet Poonia¹, Mazen Sharaf², Ric M Procyshyn³, Randal White⁴, Reza Rafizadeh⁵

Affiliations

¹ , BSc(Pharm), RPh, is a Clinical Pharmacist Tertiary Mental Health with Lower Mainland Pharmacy Services, Vancouver, British Columbia.
² , BSc(Pharm), ACPR, RPh, is a Clinical Pharmacist with the BC Psychosis Program, Lower Mainland Pharmacy Services, Vancouver, British Columbia.
³ , BSc(Pharm), MSc, PharmD, PhD, is a Clinical Professor in the Department of Psychiatry, The University of British Columbia, Vancouver, British Columbia.
⁴ , MD, FRCPC, is Clinical Director of the BC Psychosis Program and a Clinical Professor in the Department of Psychiatry, The University of British Columbia, Vancouver, British Columbia.
⁵ , BSc(Pharm), ACPR, BCPP, RPh, is a Clinical Pharmacy Specialist with BC Mental Health & Substance Use Services, BC Psychosis Program, Lower Mainland Pharmacy Services, Vancouver, British Columbia.

PMID: 35847467
PMCID: PMC9245404
DOI: 10.4212/cjhp.3178

Erratum in

Correction to "Amisulpride Augmentation of Clozapine in Clozapine-Resistant Schizophrenia: A Case Series".
[No authors listed] [No authors listed] Can J Hosp Pharm. 2022 Oct 3;75(4):346. doi: 10.4212/cjhp.3379. eCollection 2022 Fall. Can J Hosp Pharm. 2022. PMID: 36246449 Free PMC article.

No abstract available

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Conflict of interest statement

Competing interests: For activities not directly related to the case series reported here, Sukhpreet Poonia and Reza Rafizadeh have received payment for leading workshops on opioid-use disorder from the British Columbia Pharmacy Association; Ric Procyshyn has received royalties from the publisher of Clinical Handbook of Psychotropic Drugs, honoraria for advisory board service from Janssen, Lundbeck, and Otsuka, and honoraria for participation on speakers’ bureaus from Janssen, Lundbeck, Otsuka, and Eisai; and Randal White has received honoraria from HLS Therapeutics and the Canadian Agency for Drugs and Technology in Health. No other competing interests were declared.

References

1. Remington G, Addington D, Honer W, Ismail Z, Raedler T, Teehan M. Guidelines for the pharmacotherapy of schizophrenia in adults. Can J Psychiatry. 2017;62(9):604–16. doi: 10.1177/0706743717720448. - DOI - PMC - PubMed
1. Howes OD, McCutcheon R, Agid O, de Bartolomeis A, van Beveren NJM, Birnbaum ML, et al. Treatment-resistant schizophrenia: Treatment Response and Resistance in Psychosis (TRRIP) Working Group consensus guidelines on diagnosis and terminology. Am J Psychiatry. 2017;174(3):216–29. doi: 10.1176/appi.ajp.2016.16050503. - DOI - PMC - PubMed
1. Potkin SG, Kane JM, Correll CU, Lindenmayer JP, Agid O, Marder SR, et al. The neurobiology of treatment-resistant schizophrenia: paths to antipsychotic resistance and a roadmap for future research. NPJ Schizophr. 2020;6 doi: 10.1038/s41537-019-0090-z. Article 1. - DOI - PMC - PubMed
1. Siskind D, Siskind V, Kisely S. Clozapine response rates among people with treatment-resistant schizophrenia: data from a systematic review and meta-analysis. Can J Psychiatry. 2017;62(11):772–7. doi: 10.1177/0706743717718167. - DOI - PMC - PubMed
1. Keepers GA, Fochtmann LJ, Anzia JM, Benjamin S, Lyness JM, Mojtabai R, et al. The American Psychiatric Association practice guideline for the treatment of patients with schizophrenia. Am J Psychiatry. 2020;177(9):868–72. doi: 10.1176/appi.ajp.2020.177901. - DOI - PubMed

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[1] Remington G, Addington D, Honer W, Ismail Z, Raedler T, Teehan M. Guidelines for the pharmacotherapy of schizophrenia in adults. Can J Psychiatry. 2017;62(9):604–16. doi: 10.1177/0706743717720448. - DOI - PMC - PubMed

[2] Remington G, Addington D, Honer W, Ismail Z, Raedler T, Teehan M. Guidelines for the pharmacotherapy of schizophrenia in adults. Can J Psychiatry. 2017;62(9):604–16. doi: 10.1177/0706743717720448. - DOI - PMC - PubMed

[3] Howes OD, McCutcheon R, Agid O, de Bartolomeis A, van Beveren NJM, Birnbaum ML, et al. Treatment-resistant schizophrenia: Treatment Response and Resistance in Psychosis (TRRIP) Working Group consensus guidelines on diagnosis and terminology. Am J Psychiatry. 2017;174(3):216–29. doi: 10.1176/appi.ajp.2016.16050503. - DOI - PMC - PubMed

[4] Howes OD, McCutcheon R, Agid O, de Bartolomeis A, van Beveren NJM, Birnbaum ML, et al. Treatment-resistant schizophrenia: Treatment Response and Resistance in Psychosis (TRRIP) Working Group consensus guidelines on diagnosis and terminology. Am J Psychiatry. 2017;174(3):216–29. doi: 10.1176/appi.ajp.2016.16050503. - DOI - PMC - PubMed

[5] Potkin SG, Kane JM, Correll CU, Lindenmayer JP, Agid O, Marder SR, et al. The neurobiology of treatment-resistant schizophrenia: paths to antipsychotic resistance and a roadmap for future research. NPJ Schizophr. 2020;6 doi: 10.1038/s41537-019-0090-z. Article 1. - DOI - PMC - PubMed

[6] Potkin SG, Kane JM, Correll CU, Lindenmayer JP, Agid O, Marder SR, et al. The neurobiology of treatment-resistant schizophrenia: paths to antipsychotic resistance and a roadmap for future research. NPJ Schizophr. 2020;6 doi: 10.1038/s41537-019-0090-z. Article 1. - DOI - PMC - PubMed

[7] Siskind D, Siskind V, Kisely S. Clozapine response rates among people with treatment-resistant schizophrenia: data from a systematic review and meta-analysis. Can J Psychiatry. 2017;62(11):772–7. doi: 10.1177/0706743717718167. - DOI - PMC - PubMed

[8] Siskind D, Siskind V, Kisely S. Clozapine response rates among people with treatment-resistant schizophrenia: data from a systematic review and meta-analysis. Can J Psychiatry. 2017;62(11):772–7. doi: 10.1177/0706743717718167. - DOI - PMC - PubMed

[9] Keepers GA, Fochtmann LJ, Anzia JM, Benjamin S, Lyness JM, Mojtabai R, et al. The American Psychiatric Association practice guideline for the treatment of patients with schizophrenia. Am J Psychiatry. 2020;177(9):868–72. doi: 10.1176/appi.ajp.2020.177901. - DOI - PubMed

[10] Keepers GA, Fochtmann LJ, Anzia JM, Benjamin S, Lyness JM, Mojtabai R, et al. The American Psychiatric Association practice guideline for the treatment of patients with schizophrenia. Am J Psychiatry. 2020;177(9):868–72. doi: 10.1176/appi.ajp.2020.177901. - DOI - PubMed

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Amisulpride Augmentation of Clozapine in Clozapine-Resistant Schizophrenia: A Case Series

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Amisulpride Augmentation of Clozapine in Clozapine-Resistant Schizophrenia: A Case Series

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