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. 2022 Jun 29:9:912136.
doi: 10.3389/fmed.2022.912136. eCollection 2022.

Potential Correlation Between Eczema and Hematological Malignancies Risk: A Systematic Review and Meta-Analysis

Zuohui Liang  1 , Jie Liu  2 , Hongxia Jin  3 , Yirong Teng  4 , Shuangyan Xu  1 , Weimin Yan  1 , Yun Zhu  1   5
Affiliations

Potential Correlation Between Eczema and Hematological Malignancies Risk: A Systematic Review and Meta-Analysis

Zuohui Liang et al. Front Med (Lausanne). .

Abstract

Background: Eczema characterized by itch, sleeplessness, and adverse effects on quality of life is associated with a risk of hematological malignancies. However, there is a controversy pertaining to whether this association implies a greater or lesser risk of hematological cancers. We aimed to explore the link between eczema and hematological malignancies risk.

Methods: We systematically searched PubMed and Embase databases from their inception to February 17, 2022. Two reviewers independently screened articles, extracted data and assessed study quality, respectively. The odds ratios and 95% confidence intervals (CIs) were pooled by using fixed or random-effects models.

Results: 29 studies involving 2,521,574 participants examined the contribution of eczema to hematological malignancies. We found that eczema significantly increased the risk of Hodgkin's lymphoma (1.44; 95% CI, 1.07-1.95), myeloma (1.15; 95% CI, 1.04-1.28), and significantly decreased the risk of lymphocytic leukemia (0.91; 95% CI, 0.84-0.99); however, it is not significantly associated with Non-Hodgkin's lymphoma, and myelocytic leukemia.

Conclusion: Eczema has been shown to be associated with the risk of hematological cancer, this association still needs to be verified in large randomized controlled trials.

Systematic review registration: https://inplasy.com/, INPLASY202260097.

Keywords: Hodgkin's lymphoma; eczema; hematological malignancies; lymphocytic leukemia; myelocytic leukemia; risk.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flow diagram summarizing the pooled analysis phases (i.e., identification, screening, eligibility assessment, and ultimate inclusion).
Figure 2
Figure 2
The association between eczema and non-Hodgkin's lymphoma risk. (A) Forest plot of the estimated effects of eczema on non-Hodgkin's lymphoma risk. (B) Sensitivity analysis conducted by recalculating the pooled results of the primary analysis following the exclusion of one study per iteration. (C) Sensitivity analysis conducted by recalculating the pooled results of the primary analysis following the exclusion of the Bernstein et al., Fabbro-Peray et al., and Grulich et al. studies. (D) Subgroup analysis of the estimated effects of eczema on non-Hodgkin's lymphoma risk by study design. (E) Begg's test indicating the lack of publication bias among such studies. (F) Egger's test indicating the lack of publication bias among such studies.
Figure 3
Figure 3
The association between eczema and Hodgkin's lymphoma risk. (A) Forest plot of the estimated effects of eczema on Hodgkin's lymphoma risk. (B) Subgroup analysis of the estimated effects of eczema on Hodgkin's lymphoma risk.
Figure 4
Figure 4
The association between eczema and lymphocytic leukemia risk. (A) Forest plot of the estimated effects of eczema on lymphocytic leukemia risk. (B) Forest plot for the subgroup analysis by region. (C) Forest plot for the subgroup analysis by cancer type. (D) Sensitivity analysis regarding the association between eczema and acute lymphocytic leukemia risk. (E) Begg's test indicating the lack of publication bias among such studies. (F) Egger's test indicating the lack of publication bias among such studies.
Figure 5
Figure 5
Forest plot of the estimated effects of eczema on myelocytic leukemia risk and the sensitivity analysis. (A) Forest plot of eczema on myelocytic leukemia risk. (B) Sensitivity analysis was conducted by recalculating the pooled results of the primary analysis following the exclusion of one study per iteration.
Figure 6
Figure 6
Forest plot of the estimated effects of eczema on myeloma risk. (A) Forest plot. (B) Forest plot for the subgroup analysis by region.
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