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Review
. 2022 Jun 29:9:910388.
doi: 10.3389/fmed.2022.910388. eCollection 2022.

Management of Cardiovascular Disease in Patients With COVID-19 and Chronic Chagas Disease: Implications to Prevent a Scourge Still Larger

Reinaldo Bulgarelli Bestetti  1 , Edimar Alcides Bocchi  2 , Renato Bestetti  1 , Victor Sarli Issa  3 , Rosemary Aparecida Furlan-Daniel  1 , Marcelo Arruda Nakazone  4
Affiliations
Review

Management of Cardiovascular Disease in Patients With COVID-19 and Chronic Chagas Disease: Implications to Prevent a Scourge Still Larger

Reinaldo Bulgarelli Bestetti et al. Front Med (Lausanne). .

Abstract

Cardiovascular diseases (CVD) are the most important cause of morbidity and mortality in the general population. Because the high prevalence of COVID-19 and chronic Chagas disease (CCD) where the latter is endemic, all such diseases will likely be observed in the same patient. While COVID-19 can provoke generalized endotheliitis, which can lead to a cytokine storm and a hyper-coagulable state culminating into in-site and at a distance thrombosis. Therefore, small-vessel coronary artery disease (CAD), cerebrovascular disease, thromboembolism, and arrhythmias are prominent findings in COVID-19. In CCD, small-vessel CAD, cardioembolic stroke, pulmonary embolism, heart failure and arrhythmias are frequently observed as a result of a similar but less intense mechanism. Consequently, the association of CCD and COVID-19 will likely increase the incidence of CVD. Thus, doctors on the frontline should be on the alert for this diagnostic possibility so that the proper treatment can be given without any delay.

Keywords: COVID-19; Chagas disease; SARS-CoV-2; Trypanosoma cruzi; cardiovascular disease.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Potential cardiovascular complications in patients with CCHD and COVID-19.
See this image and copyright information in PMC

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