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Review
. 2022 Jun 30:12:895374.
doi: 10.3389/fonc.2022.895374. eCollection 2022.

Bone Invasive Meningioma: Recent Advances and Therapeutic Perspectives

Hajime Takase  1   2 , Tetsuya Yamamoto  2
Affiliations
Review

Bone Invasive Meningioma: Recent Advances and Therapeutic Perspectives

Hajime Takase et al. Front Oncol. .

Abstract

Meningioma is the most common primary neoplasm of the central nervous system (CNS). Generally, these tumors are benign and have a good prognosis. However, treatment can be challenging in cases with aggressive variants and poor prognoses. Among various prognostic factors that have been clinically investigated, bone invasion remains controversial owing to a limited number of assessments. Recent study reported that bone invasion was not associated with WHO grades, progression, or recurrence. Whereas, patients with longer-recurrence tended to have a higher incidence of bone invasion. Furthermore, bone invasion may be a primary preoperative predictor of the extent of surgical resection. Increasing such evidence highlights the potential of translational studies to understand bone invasion as a prognostic factor of meningiomas. Therefore, this mini-review summarizes recent advances in pathophysiology and diagnostic modalities and discusses future research directions and therapeutic strategies for meningiomas with bone invasion.

Keywords: bone invasion; long-term; meningioma; recurrence; translational study.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
A representative case of meningioma with bone invasion. Axial (A, C, E) and coronal (B, D, F) images demonstrating a petroclival meningioma. (A, B) T1-post contrast MRI shows a characteristic dural tail (white arrows). Enhancement in the adjacent bone is ambiguous, and no obvious laterality is found (yellow arrows). (C, D) Non-contrast bone CT does not reveal a hyperostosis with tumor-associated laterality. (E, F) However, F18 fluoride PET/CT fusion image indicates prominent uptake in the adjacent bone suggesting bone invasion of the tumor (white arrowheads).
Figure 2
Figure 2
Histopathology of the case of bone invasive meningioma shown in Figure 1 . (A) H&E staining demonstrating a cellular/tissue invasion into bone trabecula. ×200 magnification. Scale bar = 200 μm. (B) H&E staining demonstrating a proliferation of tumor cells with round to oval nuclei. Whorl formation of the tumor cells suggests meningothelial meningioma (WHO grade 1). ×400 magnification, Scale bar = 100 μm.
Figure 3
Figure 3
Summary of prognostic factors of meningioma and their potential relationship with bone invasion.
See this image and copyright information in PMC

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