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. 2022 Jul;23(4):302-305.
doi: 10.5152/TurkThoracJ.2022.21273.

Coexistence of Multiple Pulmonary Sclerosing Pneumocytoma and Scleroderma-Rheumatoid Arthritis Overlap Syndrome: A Case Report

Hülya Abalı  1 , Fatma Tokgöz Akyıl  1 , Seda Tural Önür  1 , Neslihan Akanıl Fener  2 , Aysun Ölçmen  3
Affiliations

Coexistence of Multiple Pulmonary Sclerosing Pneumocytoma and Scleroderma-Rheumatoid Arthritis Overlap Syndrome: A Case Report

Hülya Abalı et al. Turk Thorac J. 2022 Jul.

Abstract

Pulmonary sclerosing pneumocytoma is a rare, low-grade pulmonary tumor observed as unilateral or bilateral multiple nodules at a rate of 4%-5%. Among the autoimmune connective tissue disorders, those most commonly associated with lung malignancies are sclero- derma and rheumatoid arthritis. In this study, we report a rare case of a 55-year-old middle-aged Asian woman with slow-growing bilat- eral multiple pulmonary sclerosing pneumocytoma and scleroderma-rheumatoid arthritis overlap syndrome. The autoimmune disorders and pulmonary fibrosis of this case might have led to the development of PSP.

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Figures

Figures 1.
Figures 1.
(A) Right lung apical juxtapleural 1.3 cm nodule (blue arrow); (B) Left lung hilar 1.5 cm nodule with overlying vessel sign (blue arrow); (C) Right lung lower lobe 2.5 cm nodule and right lung middle lobe, paracardiac, irregularly circumscribed 3 cm diameter consolidation and bilateral lung lower lobe consolidations on contrast-enhanced Thoracic CT (August 25, 2021); (D) Right apical, juxtapleural 1.3 cm nodule (blue arrow) (SUVmax:3.6); (E) Left hilar 1.5 cm nodule (blue arrow) (SUVmax:3.4); (F) Right lower lobe 2.5 cm nodule (SUVmax:4.9) (blue arrow) and right middle lobe, paracardiac, irregularly circumscribed 3 cm diameter consolidation and bilateral lower lobe consolidations (SUVmax:3.6) on PET-CT. PET, positron emission tomography; CT, computed tomography
Figures 1.
Figures 1.
(A) Right lung apical juxtapleural 1.3 cm nodule (blue arrow); (B) Left lung hilar 1.5 cm nodule with overlying vessel sign (blue arrow); (C) Right lung lower lobe 2.5 cm nodule and right lung middle lobe, paracardiac, irregularly circumscribed 3 cm diameter consolidation and bilateral lung lower lobe consolidations on contrast-enhanced Thoracic CT (August 25, 2021); (D) Right apical, juxtapleural 1.3 cm nodule (blue arrow) (SUVmax:3.6); (E) Left hilar 1.5 cm nodule (blue arrow) (SUVmax:3.4); (F) Right lower lobe 2.5 cm nodule (SUVmax:4.9) (blue arrow) and right middle lobe, paracardiac, irregularly circumscribed 3 cm diameter consolidation and bilateral lower lobe consolidations (SUVmax:3.6) on PET-CT. PET, positron emission tomography; CT, computed tomography
Figures 2.
Figures 2.
(A) Neoplastic epithelial cells lining around the fibrovascular core (H&E 10×10); (B) Neoplastic epithelial cells with columnar, eccentric core, eosinophilic cytoplasm around the fibrovascular core (H & E 40×10), C. Strong diffuse immune reaction in neoplastic epithelial cells with TTF-1 (20×10). H & E, hematoxylin and eosin; TTF-1, thyroid transcription factor-1.
See this image and copyright information in PMC

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