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Case Reports
. 2022 Jul-Sep;68(3):168-169.
doi: 10.4103/jpgm.jpgm_1059_21.

Levetiracetam-induced gingival hyperplasia

J James  1 , J Jose  1 , V A Gafoor  1
Affiliations
Case Reports

Levetiracetam-induced gingival hyperplasia

J James et al. J Postgrad Med. 2022 Jul-Sep.

Abstract

Levetiracetam is a new generation antiseizure medication which binds to synaptic vesicle protein SV2A and inhibits the release of neurotransmitters. Gingival hyperplasia is a common side effect of conventional antiseizure medications like phenytoin, but very rare with the newer ones. A 14-year-old boy was started on levetiracetam 250 mg twice daily after a generalized seizure. Five days later he presented with gingival swelling and painful oral aphthae, without lymphadenopathy or systemic symptoms. Blood investigations were normal. After one-month of stopping the drug, the lesions cleared. This case highlights the importance of maintaining good oral hygiene and periodic dental review in patients on antiseizure medications.

Keywords: Anticonvulsants; gingival hyperplasia; levetiracetam.

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Conflict of interest statement

None

Figures

Figure 1
Figure 1
(a) Gingival hyperplasia is seen over the upper and lower gums (arrows). (b) Aphthous ulcers are seen along the upper inner gums (arrow)
See this image and copyright information in PMC

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References

    1. Lyseng-Williamson KA. Spotlight on levetiracetam in epilepsy. CNS Drugs. 2011;25:901–5. - PubMed
    1. Mbizvo GK, Dixon P, Hutton JL, Marson AG. The adverse effects profile of levetiracetam in epilepsy: A more detailed look. Int J Neurosci. 2014;124:627–34. - PubMed
    1. Bharti V, Bansal C. Drug-induced gingival overgrowth: The nemesis of gingiva unravelled. J Indian Soc Periodontol. 2013;17:182–7. - PMC - PubMed
    1. Meraw SJ, Sheridan PJ. Medically induced gingival hyperplasia. Mayo Clin Proc. 1998;73:1196–9. - PubMed
    1. Informational paper: Drug-associated gingival enlargement. J Periodontol. 2004;75:1424–31. - PubMed

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