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Editorial
. 2022 Jul 29;145(7):2236-2238.
doi: 10.1093/brain/awac172.

Towards adaptive deep brain stimulation for freezing of gait

Huiling Tan  1
Affiliations
Editorial

Towards adaptive deep brain stimulation for freezing of gait

Huiling Tan. Brain. .

Abstract

This scientific commentary refers to ‘Cortical phase-amplitude coupling is key to the occurrence and treatment of freezing of gait’ by Yin et al. (https://doi.org/10.1093/brain/awac121).

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Figures

Figure 1
Figure 1
Schematic showing the key findings of Yin and colleagues. (A) Potentials from primary motor cortex were recorded from patients with Parkinson’s disease undergoing surgery for DBS. (B) Beta-gamma PAC in the motor cortex was observed, which can arise from either nested oscillations, or deflected waveforms in the beta frequency bands, or both (adapted from Cole et al. and Vaz et al.). (C) PAC in motor cortex decreased during walking compared to standing, but temporarily increased during states vulnerable to freezing, compared with normal walking. (D) STN stimulation reduced the baseline PAC and increased the dynamic range of PAC for normal functioning.
See this image and copyright information in PMC

Comment on

References

    1. Little S, Brown P. What brain signals are suitable for feedback control of deep brain stimulation in Parkinson’s disease? Ann N Y Acad Sci. 2012;1265:9–24. - PMC - PubMed
    1. Yin Z, Zhu G, Liu Y, et al. . Cortical phase-amplitude coupling is key to the occurrence and treatment of freezing of gait. Brain. 2022;145(7):2407–2421. - PMC - PubMed
    1. Cole SR, van der Meij R, Peterson EJ, de Hemptinne C, Starr PA, Voytek B. Nonsinusoidal beta oscillations reflect cortical pathophysiology in Parkinson’s disease. J Neurosci. 2017;37:4830–4840. - PMC - PubMed
    1. Vaz AP, Yaffe RB, Wittig JH, Inati SK, Zaghloul KA. Dual origins of measured phase-amplitude coupling reveal distinct neural mechanisms underlying episodic memory in the human cortex. NeuroImage. 2017;148:148–159. - PMC - PubMed
    1. Singh A, Plate A, Kammermeier S, Mehrkens JH, Ilmberger J, Bötzel K. Freezing of gait-related oscillatory activity in the human subthalamic nucleus. Basal Ganglia. 2013;3:25–32.

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