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Meta-Analysis
. 2022 Aug;42(4):487-492.
doi: 10.19852/j.cnki.jtcm.2022.04.001.

Effectiveness of redcore lotion in patients with vulvovaginal candidiasis: a systematic review and Meta-analysis

Ding Lijuan  1 , Yin Lu  1 , Wang Liping  1 , Sun Yaya  1 , Liu Xiaoyun  1 , L I Xiangrong  1
Affiliations
Meta-Analysis

Effectiveness of redcore lotion in patients with vulvovaginal candidiasis: a systematic review and Meta-analysis

Ding Lijuan et al. J Tradit Chin Med. 2022 Aug.

Abstract

Objective: To summarize and evaluate the effectiveness and safety of Redcore lotion on treating vulvovaginal candidiasis (VVC) using a systematic review and Meta-analysis of randomized controlled trials.

Methods: A systematic literature search was performed in five English and three Chinese electronic databases up to October 2019. Randomized controlled trials in the treatment for VVC were included; only studies which compared the effectiveness and safety of Redcore lotion plus miconazole with miconazole alone were included. Relative risk (RR) and 95% confidence intervals (CI) were used in the Meta-analysis.

Results: Seven studies involving 768 patients suffering from VVC were identified; 468 of the patients were pregnant women (60.9%). Combination group (Redcore lotion plus miconazole) was more effective in reduCIng symptomatic episodes of VVC than miconazole alone, with respect to cure rate (RR, 1.31; 95% CI, 1.09-1.57; P = 0.01), fungal culture negative rate (RR, 1.21; 95% CI, 1.04-1.41; P = 0.01), and effective rate (RR, 1.18; 95% CI, 1.05-1.35; P = 0.01). Subgroup analyses for pregnant women also showed that the combination group had superior outcomes with respect to VVC cure rate (RR, 1.48; 95% CI, 1.16-1.88, P < 0.01), fungal culture negative rate (RR, 1.26; 95% CI; 1.09-1.47; P < 0.01), and effective rate (RR, 1.25; 95% CI, 1.10-1.42; P < 0.01). Additionally, the observed risk of adverse events was lower in the combination medication group (RR, 0.30; 95% CI, 0.14-0.65; P < 0.01).

Conclusions: Though overall quality of individual studies was low, Redcore lotion plus miconazole can significantly improve clinical effectiveness and safety compared with miconazole alone.

Keywords: Meta-analysis; Redcore lotion; candidiasis, vulvovaginal; miconazole; systematic review.

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Figures

Figure 1
Figure 1. Forest plots for r treatment effect of redcore lotion plus miconazole vs miconazole alone
A: vulvovaginal candidiasis cure rate; B: fungal culture negative rate; C: effective rate. Redcore lotion plus miconazole vs miconazole alone.
See this image and copyright information in PMC

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