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Meta-Analysis
. 2022 Aug;42(4):487-492.
doi: 10.19852/j.cnki.jtcm.2022.04.001.

Effectiveness of redcore lotion in patients with vulvovaginal candidiasis: a systematic review and Meta-analysis

Ding Lijuan  1 , Yin Lu  1 , Wang Liping  1 , Sun Yaya  1 , Liu Xiaoyun  1 , L I Xiangrong  1
Affiliations
Meta-Analysis

Effectiveness of redcore lotion in patients with vulvovaginal candidiasis: a systematic review and Meta-analysis

Ding Lijuan et al. J Tradit Chin Med. 2022 Aug.

Abstract

Objective: To summarize and evaluate the effectiveness and safety of Redcore lotion on treating vulvovaginal candidiasis (VVC) using a systematic review and Meta-analysis of randomized controlled trials.

Methods: A systematic literature search was performed in five English and three Chinese electronic databases up to October 2019. Randomized controlled trials in the treatment for VVC were included; only studies which compared the effectiveness and safety of Redcore lotion plus miconazole with miconazole alone were included. Relative risk (RR) and 95% confidence intervals (CI) were used in the Meta-analysis.

Results: Seven studies involving 768 patients suffering from VVC were identified; 468 of the patients were pregnant women (60.9%). Combination group (Redcore lotion plus miconazole) was more effective in reduCIng symptomatic episodes of VVC than miconazole alone, with respect to cure rate (RR, 1.31; 95% CI, 1.09-1.57; P = 0.01), fungal culture negative rate (RR, 1.21; 95% CI, 1.04-1.41; P = 0.01), and effective rate (RR, 1.18; 95% CI, 1.05-1.35; P = 0.01). Subgroup analyses for pregnant women also showed that the combination group had superior outcomes with respect to VVC cure rate (RR, 1.48; 95% CI, 1.16-1.88, P < 0.01), fungal culture negative rate (RR, 1.26; 95% CI; 1.09-1.47; P < 0.01), and effective rate (RR, 1.25; 95% CI, 1.10-1.42; P < 0.01). Additionally, the observed risk of adverse events was lower in the combination medication group (RR, 0.30; 95% CI, 0.14-0.65; P < 0.01).

Conclusions: Though overall quality of individual studies was low, Redcore lotion plus miconazole can significantly improve clinical effectiveness and safety compared with miconazole alone.

Keywords: Meta-analysis; Redcore lotion; candidiasis, vulvovaginal; miconazole; systematic review.

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Figures

Figure 1
Figure 1. Forest plots for r treatment effect of redcore lotion plus miconazole vs miconazole alone
A: vulvovaginal candidiasis cure rate; B: fungal culture negative rate; C: effective rate. Redcore lotion plus miconazole vs miconazole alone.
See this image and copyright information in PMC

References

    1. Liu XP, Fan SR, Peng YT, et al. Species distribution and susceptibility of Candida isolates from patient with vulvovaginal candidiasis in Southern China from 2003 to 2012. J Mycol Med 2014; 24: 106-11. - PubMed
    1. Shi XY, Yang YP, Zhang Y, et al. Molecular identification and antifungal susceptibility of 186 Candida isolates from vulvovaginal candidiasis in southern China. J Med Microbiol 2015; 64: 390-3. - PubMed
    1. Fakhim H, Vaezi A, Javidnia J, et al. Candida africana vulvovaginitis: prevalence and geographical distribution. J Mycol Med 2020; 30: 100966. - PubMed
    1. Workowski KA. Centers for disease control and prevention sexually transmitted diseases treatment guidelines. Clin Infect Dis 2015; 61: S759-62. - PubMed
    1. Yano J, Soble JD, Nyirjesy P, et al. Current patient perspectives of vulvovaginal candidiasis: incidence, symptoms, management and post-treatment outcomes. BMC Womens Health 2019; 19: 48. - PMC - PubMed