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. 2022 Aug;12(8):e2718.
doi: 10.1002/brb3.2718. Epub 2022 Jul 18.

Geriatric Nutritional Risk Index is related to the risk of stroke-associated pneumonia

Caijun Dai  1 , Dan Yan  1 , Minjie Xu  2 , Qiqi Huang  3 , Wenwei Ren  2
Affiliations

Geriatric Nutritional Risk Index is related to the risk of stroke-associated pneumonia

Caijun Dai et al. Brain Behav. 2022 Aug.

Abstract

Background: Stroke-associated pneumonia (SAP) occurs frequently after a stroke. Geriatric Nutritional Risk Index (GNRI) is a valuable indicator of elderly individuals' nutritional status. This research was designed to obtain insight into the link between GNRI and SAP.

Methods: Patients with acute ischemic stroke (AIS) were categorized into the SAP and non-SAP groups. GNRI scores were divided into four layers: Q1, GNRI < 82; Q2, 82≤ GNRI < 92; Q3, 92≤ GNRI ≤98; Q4, GNRI > 98. To identify the independent risk and protective factors of developing SAP, logistic regression analyses were conducted. Additionally, we utilized the restricted cubic spline (RCS) analysis to test the effect of GNRI on the SAP risk.

Results: The SAP group showed lower GNRI scores than the non-SAP group (96.88 ± 9.36 vs. 100.88 ± 8.25, p < 0.001). According to the logistic regression model, the Q1 and Q2 layers showed a higher risk of SAP than the Q3 layer, while the Q4 layer showed a lower SAP risk (all p < 0.05). Besides, the RCS model found that the risk of SAP dropped dramatically as GNRI scores increased, which got stable when the GNRI score was more significant than 100.

Conclusion: Lower GNRI scores were linked to a higher prevalence of SAP. In clinical practice, GNRI showed predictive value for SAP, which could be helpful in early SAP intervention and therapy.

Keywords: Geriatric Nutritional Risk Index (GNRI); pneumonia; stroke.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

FIGURE 1
FIGURE 1
Flowchart of participants. SAP: stroke‐associated pneumonia
FIGURE 2
FIGURE 2
Forest plot of odds ratios (OR) for SAP. An OR > 1 meant an increased risk of SAP, and an OR < 1 meant the opposite. SAP: stroke‐associated pneumonia; GNRI: Geriatric Nutritional Risk Index; NIHSS: National Institutes of Health Stroke Scale score
FIGURE 3
FIGURE 3
Association between GNRI and risk of SAP using restricted cubic spline (RCS) analysis. SAP: stroke‐associated pneumonia; GNRI: Geriatric Nutritional Risk Index
See this image and copyright information in PMC

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