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. 2022 Oct;42(10):1032-1035.
doi: 10.1002/cac2.12336. Epub 2022 Jul 19.

Genomic profiling and the impact of MUC19 mutation in hepatoid adenocarcinoma of the stomach

Mengxuan Zhu  1   2 , Erbao Chen  3 , Shan Yu  1   2 , Chen Xu  4 , Yiyi Yu  1 , Xin Cao  5 , Wei Li  1 , Pengfei Zhang  1 , Yan Wang  1 , Baofeng Lian  6 , Shuirong Zhang  6 , Yueting Qu  6 , Lujia Huang  6 , Weiwei Shi  6 , Yuehong Cui  1   2 , Li Qian  1   2   7 , Tianshu Liu  1   2   7
Affiliations

Genomic profiling and the impact of MUC19 mutation in hepatoid adenocarcinoma of the stomach

Mengxuan Zhu et al. Cancer Commun (Lond). 2022 Oct.
No abstract available

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Conflict of interest statement

No conflicts of interest to disclose.

Figures

FIGURE 1
FIGURE 1
Genomic profiling for HAS patients and validation of MUC19 as a critical gene for HAS development. (A) The mutation and CNV landscape of 40 patients. (B) The heatmap of CNV in the HAS. (C) Illustration of one case with CNV in chr19q12. (D) The TMB in four groups (our cohort, STAD, HCC, CRC) were compared. (E) The TMB in the subgroups of our cohort. (F) High degree of TMB was associated with better OS in HAS samples. (G) Western blot demonstrating levels of AFP in gastric cancer cells. Compared with cells transfected with control vector, the cells transfected with MUC19 overexpression lentivirus had higher AFP expression. (H) Representative immunohistochemical staining images show the expression of AFP and MUC19 in HAS tumors (upper); scale bar represents 50 μm; the correlation between immunohistochemistry staining intensity for AFP and MUC19 in HAS patients from the validation cohort (bottom). (I) Statistic analysis of invasion assay for GC cells with different MUC19 expressions. (J) Subcutaneous xenograft tumor model was established by injection of MUC19 overexpression (MUC19) or control HGC27 cells (Control). The photography of xenograft tumors after 4 weeks subcutaneous implantation of cells. (K, L) The xenograft tumor weight (K) and volume (L) were measured. (M) Subcellular localization of β‐catenin was assessed by immunofluorescence staining. Data are presented as means ± SEM. * P < 0.05, *** P < 0.005, ns, not significant.
See this image and copyright information in PMC

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