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. 2022 Dec;407(8):3249-3258.
doi: 10.1007/s00423-022-02606-5. Epub 2022 Jul 19.

The role of bariatric surgery in liver transplantation: timing and type

Danial Safavi  1 , Ben Creavin  2 , Tom K Gallagher  3   4 , Michael E Kelly  3   5
Affiliations

The role of bariatric surgery in liver transplantation: timing and type

Danial Safavi et al. Langenbecks Arch Surg. 2022 Dec.

Abstract

Introduction: The rise in obesity worldwide has shifted the indications for liver transplantation (LT), with non-alcoholic steatohepatitis (NASH) being the second most common indication for transplantation. There remains an underestimation of cirrhosis being attributed to NASH. Bariatric surgery (BS) is a reliable solution to overcome obesity and its associated comorbidities. The role of BS in LT has been investigated by different studies; however, the type of BS and timing of LT need further investigation.

Methods: A systemic review examining the role of BS in LT patients was performed. After selection of the studies based on inclusion and exclusion criteria, data extraction was performed by two independent reviewers. Primary outcomes included patient and graft survival.

Results: From a total of 2374 articles, five met the prefined criteria. One hundred sixty-two patients had both BS + LT and 1426 underwent LT alone. The percentage of female patients in the BS + LT and LT cohorts was 75% and 35% respectively. The average age in BS + LT and LT cohorts was 43.05 vs. 56.22 years respectively. Patients undergoing BS had comparable outcomes in terms of overall patient survival, graft survival and post-operative morbidity compared to LT alone. When comparing BMI change in patients with prior versus simultaneous BS + LT, no significant difference was found.

Conclusion: BS and LT patients achieve comparable outcomes to general LT populations. Further studies examining simultaneous BS + LT are needed to answer questions concerning patient selection and timing of surgery.

Keywords: Bariatric surgery; Gastric bypass; Liver transplantation; Sleeve gastrectomy; Weight loss surgery.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Prisma flow diagram outlining the process of study selection
Fig. 2
Fig. 2
Forest plot comparison of outcomes: A change in BMI in patients with prior BS vs. simultaneous BS, B overall survival, C graft failure, D post-operative morbidity
See this image and copyright information in PMC

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