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Observational Study
. 2024 Apr-Jun;102(2):84-95.
doi: 10.1080/00185868.2022.2096523. Epub 2022 Jul 19.

Clinico-Epidemiological Characteristics of Healthcare Workers with SARS-CoV-2 Infection during the First and Second Waves in a Teaching Hospital from Eastern India: A Comparative Analysis

Arvind Kumar Singh  1 , Manoj Kumar Panigrahi  2 , Somen Kumar Pradhan  1 , Debkumar Pal  1 , Sonu H Subba  1 , Binod Kumar Patro  1 , Binod Kumar Behera  1 , Baijayantimala Mishra  3 , Bijayini Behera  3 , Prasanta Raghab Mohapatra  2 , Sourin Bhuniya  2 , Shakti Kumar Bal  2 , Saurav Sarkar  4 , Jawahar S K Pillai  5 , Sachidananda Mohanty  6 , Batmanabane Gitanjali  6 ; AIIMS Bhubaneswar COVID-19 Study Group
Affiliations
Observational Study

Clinico-Epidemiological Characteristics of Healthcare Workers with SARS-CoV-2 Infection during the First and Second Waves in a Teaching Hospital from Eastern India: A Comparative Analysis

Arvind Kumar Singh et al. Hosp Top. 2024 Apr-Jun.

Abstract

In this retrospective observational study, we have performed a comparative analysis of the demographic, clinical and epidemiological characteristics of the HCWs affected with SARS-CoV-2 infection during first two waves in India. The overall prevalence of SARS-CoV-2 infection among HCWs was found to be 15.24% (14.20-16.33) and 23.38% (22.14-25.65) during first and second waves respectively. The second wave showed an adjusted odds ratio of 0.04(0.02-0.07) and 2.09(1.49-2.93) for hospitalization and being symptomatic, respectively. We detected significantly higher level of C-reactive protein (CRP) among admitted HCWs during the second wave (5.10 -14.60 mg/dl) as compared to the first wave (2.00 - 2.80 mg/dl). Our study found the relative risk of SARS-CoV-2 reinfection among HCWs during the second wave to be 0.68 [0.57-0.82, p < 0.001)]. Although, the prevalence of SARS CoV-2 infection and risk of being symptomatic was higher during second wave, the risk of hospitalization was less when compared with the first wave.

Keywords: Health care worker; SARS CoV-2; hospital; pandemic.

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