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. 2023:280:85-106.
doi: 10.1007/164_2022_598.

Precision Medicine in Asthma Therapy

Stefania Principe  1   2 , Susanne J H Vijverberg  3 , Mahmoud I Abdel-Aziz  3   4 , Nicola Scichilone  5 , Anke H Maitland-van der Zee  3
Affiliations

Precision Medicine in Asthma Therapy

Stefania Principe et al. Handb Exp Pharmacol. 2023.

Abstract

Asthma is a complex, heterogeneous disease that necessitates a proper patient evaluation to decide the correct treatment and optimize disease control. The recent introduction of new target therapies for the most severe form of the disease has heralded a new era of treatment options, intending to treat and control specific molecular pathways in asthma pathophysiology. Precision medicine, using omics sciences, investigates biological and molecular mechanisms to find novel biomarkers that can be used to guide treatment selection and predict response. The identification of reliable biomarkers indicative of the pathological mechanisms in asthma is essential to unravel new potential treatment targets. In this chapter, we provide a general description of the currently available -omics techniques, focusing on their implications in asthma therapy.

Keywords: Asthma; Biomarkers; Omics; Precision medicine.

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