Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2022 Jul 12:15:367-371.
doi: 10.2147/IMCRJ.S371745. eCollection 2022.

Sensorineural Hearing Loss in Juvenile CML: A Rare Case Report in Surabaya, Indonesia

Ihda Kartika Syamsuddin  1 , Paulus Budiono Notopuro  2
Affiliations
Case Reports

Sensorineural Hearing Loss in Juvenile CML: A Rare Case Report in Surabaya, Indonesia

Ihda Kartika Syamsuddin et al. Int Med Case Rep J. .

Abstract

Chronic myeloid leukemia (CML) is a type of myeloproliferative neoplasm (MPN) in which granulocytes are the primary proliferating cells. CML in pediatric patients (juvenile CML) is an uncommon MPN, representing 2-3% of children newly diagnosed with leukemia. Sensorineural hearing loss that progresses rapidly is an uncommon early sign of a hematological disorder in patients with CML. This article presents the case of a 10-year-old patient with complaints of bilateral hearing loss for 2 weeks. Pure-tone audiometry indicated sensorineural hearing loss of the left ear and mixed hearing loss of the right ear. After an in-depth evaluation of a bone marrow smear and positivity for the BCR-ABL fusion gene, it was concluded that the patient had chronic-phase juvenile CML. However, hearing loss recovery after hydroxyurea therapy could not be observed because the patient died after suffering an uncontrolled seizure on day 14 of hospitalization.

Keywords: BCR-ABL; cancer; chronic myeloid leukemia; pediatric; sensorineural hearing loss.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Bone marrow examination using Wright’s stain (1000× magnification) showing hypercellular marrow with 8% myeloblasts.
Figure 2
Figure 2
Pure-tone audiometry results.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Athale U, Hijiya N, Patterson BC, et al. Management of chronic myeloid leukemia in children and adolescents: recommendations from the children’s oncology group CML working group. Pediatr Blood Cancer. 2019;66(9):e27827. doi:10.1002/pbc.27827 - DOI - PMC - PubMed
    1. Swerdlow SH, Thiele J, Vardiman JW, et al. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Geneva: WHO press; 2017.
    1. Cass ND, Gubbels SP, Portnuff CDF. Sudden bilateral hearing loss, tinnitus, and vertigo as presenting symptoms of chronic myeloid leukemia. Ann Otol Rhinol Laryngol. 2018;127(10):731–734. doi:10.1177/0003489418787831 - DOI - PubMed
    1. Hijiya N, Schultz KR, Metzler M, et al. Pediatric chronic myeloid leukemia is a unique disease that requires a different approach. Blood. 2016;127(4):392–399. doi:10.1182/blood-2015-06-648667 - DOI - PMC - PubMed
    1. Kayode AS, Adeleke IA, Oluwatona DA. Sudden sensorineural hearing loss in patient with chronic myelogenous leukemia – a case study. Arch Otolaryngol Rhinol. 2018;4(4):082–084. doi:10.17352/aor - DOI

Publication types