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Case Reports
. 2022 Jul 12:15:367-371.
doi: 10.2147/IMCRJ.S371745. eCollection 2022.

Sensorineural Hearing Loss in Juvenile CML: A Rare Case Report in Surabaya, Indonesia

Ihda Kartika Syamsuddin  1 , Paulus Budiono Notopuro  2
Affiliations
Case Reports

Sensorineural Hearing Loss in Juvenile CML: A Rare Case Report in Surabaya, Indonesia

Ihda Kartika Syamsuddin et al. Int Med Case Rep J. .

Abstract

Chronic myeloid leukemia (CML) is a type of myeloproliferative neoplasm (MPN) in which granulocytes are the primary proliferating cells. CML in pediatric patients (juvenile CML) is an uncommon MPN, representing 2-3% of children newly diagnosed with leukemia. Sensorineural hearing loss that progresses rapidly is an uncommon early sign of a hematological disorder in patients with CML. This article presents the case of a 10-year-old patient with complaints of bilateral hearing loss for 2 weeks. Pure-tone audiometry indicated sensorineural hearing loss of the left ear and mixed hearing loss of the right ear. After an in-depth evaluation of a bone marrow smear and positivity for the BCR-ABL fusion gene, it was concluded that the patient had chronic-phase juvenile CML. However, hearing loss recovery after hydroxyurea therapy could not be observed because the patient died after suffering an uncontrolled seizure on day 14 of hospitalization.

Keywords: BCR-ABL; cancer; chronic myeloid leukemia; pediatric; sensorineural hearing loss.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Bone marrow examination using Wright’s stain (1000× magnification) showing hypercellular marrow with 8% myeloblasts.
Figure 2
Figure 2
Pure-tone audiometry results.
See this image and copyright information in PMC

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