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. 2022 Jul 9:2022:7646361.
doi: 10.1155/2022/7646361. eCollection 2022.

The Effect of Propofol plus Remifentanil for PostoperativePain and Heart Rate Management in Patients Undergoing Abdominal Hysterectomy

Li Zhang  1 , Yuping Wang  1 , Longxin Zhang  1 , Xiaofen Chen  1 , Min Zhou  1
Affiliations

The Effect of Propofol plus Remifentanil for PostoperativePain and Heart Rate Management in Patients Undergoing Abdominal Hysterectomy

Li Zhang et al. Evid Based Complement Alternat Med. .

Retraction in

Abstract

Purpose: To explore the effect of propofol plus remifentanil for postoperative pain and heart rate management in patients undergoing abdominal hysterectomy.

Methods: In this prospective randomized controlled study, 96 patients who underwent abdominal hysterectomy in an affiliated hospital of Fujian Medical University from April 2016 to April 2017 were recruited and randomized into the study group (n = 48) and control group (n = 48) via the random number table method. The control group received remifentanil for anesthesia, and the study group was given propofol plus remifentanil. The postoperative pain and heart rates of patients were compared between the two groups.

Results: No significant difference was observed in the heart rate and adrenaline values between the two groups before anesthesia, and the study group had significantly lower adrenaline values and heart rates intraoperatively and 15 min after operation than the control group. Patients in the study group showed shorter time-lapse before independent breathing recovery, extubation, and resuscitation compared to those in the control group. The study group received less patient-controlled intravenous analgesia (PCIA) as compared to the study group within 48 h after operation. In the study group, the numeric rating scale (NRS) scores within 1 h, 2 h, 6 h, 8 h, and 12 h after operation were significantly lower than those in the control group (P < 0.001). Propofol plus remifentanil offer a viable alternative for postoperative pain management and stress alleviation after abdominal hysterectomy with a high safety profile. Further clinical trials are, however, required prior to clinical promotion.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Comparison of adrenaline levels at different times. The X-axis represents the D1, D2, and D3, and the Y-axis represents the adrenaline level at different times (ng/L). ∗∗∗P < 0.001.
Figure 2
Figure 2
Comparison of heart rate at different times. The X-axis represents the times of the D1, D2, D3, and the Y-axis represents the heart rate at different times (beats/min). ∗∗∗P < 0.001.
Figure 3
Figure 3
Comparison of PICA times. The X-axis represents the different groups and the Y-axis represents the PICA times. ∗∗∗P < 0.001.
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