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Review
. 2022 Jul 12:80:104170.
doi: 10.1016/j.amsu.2022.104170. eCollection 2022 Aug.

The relationship between folic acid and colorectal cancer; a literature review

Haidara Kherbek  1 , Rima Daoud  1 , Tania Soueycatt  1 , Youssef Soueycatt  1 , Zain Ali  1 , Julia Ehsan  1 , Zuheir Alshehabi  2 , Michael Georgeos  3
Affiliations
Review

The relationship between folic acid and colorectal cancer; a literature review

Haidara Kherbek et al. Ann Med Surg (Lond). .

Abstract

The objective: this study aims to investigate the relationship between folic acid and colorectal cancer (CRC).

Methods: google scholar, Pubmed, Pubmed central were searched from 1994 to 2022 for articles on the association between folic acid and CRC using the combinations: folic acid and colorectal cancer risk, folic acid and colorectal cancer survival, folic acid and colorectal cancer recurrence.

Main message: to describe and discuss the effect that folic acid might play on colorectal cancer (CRC) risk, recurrence and survivals, taking into account the possible differences between the men and women.

Conclusion: Our article supports the idea that says: vit-B9 has a dual-modulator effect on CRC carcinogenesis. However, its role in preventing recurrence and improving survival rates remains unresolved with a possible potential role of folate metabolism genotype variations. Therefore, more evidence from clinical studies is needed.

Keywords: Colorectal cancer; Folic acid; Recurrence; Risk; Survival.

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Conflict of interest statement

No conflict of interest.

Figures

Fig. 1
Fig. 1
Vit-B9 has a dual-modulator effect on CRC carcinogenesis.
See this image and copyright information in PMC

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References

    1. Yuan Zhong, Zhu Yan, Li Quanpeng, Wang Fei, Ge Xianxiu, Zhou Guangxin, Lin Miao. Association between Mediterranean diet adherence and colorectal cancer: a dose-response meta-analysis. Am. J. Clin. Nutr. June 2020;111(6):1214–1225. doi: 10.1093/ajcn/nqaa083. - DOI - PubMed
    1. Schwingshackl Lukas, et al. Adherence to mediterranean diet and risk of cancer: an updated systematic review and meta-analysis. Nutrients. 2017;9(10):1063. (Crossref. Web) - PMC - PubMed
    1. Shaukat Aasma, et al. Role of supplemental calcium in the recurrence of colorectal adenomas: a metaanalysis of randomized controlled trials. Am. J. Gastroenterol. 2005;100(2):390–394. doi: 10.1111/j.1572-0241.2005.41220.x. - DOI - PubMed
    1. Kim Y.-I. Folate: a magic bullet or a double edged sword for colorectal cancer prevention? Gut. 2006;55(10):1387–1389. doi: 10.1136/gut.2006.095463. - DOI - PMC - PubMed
    1. Hubner R.A., Houlston R.S. Folate and colorectal cancer prevention. Br. J. Cancer. 2009;100(2):233–239. doi: 10.1038/sj.bjc.6604823. - DOI - PMC - PubMed