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. 2022 Sep;5(5):e357.
doi: 10.1002/edm2.357. Epub 2022 Jul 20.

Thyroid disease-specific quality of life questionnaires - A systematic review

Verena Uslar  1 , Caroline Becker  1 , Dirk Weyhe  1 , Navid Tabriz  1
Affiliations

Thyroid disease-specific quality of life questionnaires - A systematic review

Verena Uslar et al. Endocrinol Diabetes Metab. 2022 Sep.

Abstract

Introduction: Thyroid diseases are very common and rarely life-threatening. One of the main therapeutic goals is an improvement in quality of life, making it important to measure in clinical and research settings. The aim of this systematic review is to provide an overview of the currently available thyroid-specific quality of life questionnaires with regard to their validation quality in order to make recommendations for clinical use with a special focus on German questionnaires.

Methods: A systematic literature search was performed in Pubmed, Google Scholar and the Cochrane Library. A total of 904 studies were identified. After excluding duplicates, non-English- or German-language texts, full texts that were not freely available and studies with irrelevant content, 64 studies reporting on 16 different questionnaires were included in the analysis.

Results: Four questionnaires concerned benign thyroid diseases (ThyPRO, ThyPRO-39, Thy-R-HRQoL and Thy-D-QOL), six malignant thyroid diseases (THYCA-QoL, ThyCa-HRLQOL, EORTC-Thy34, MADSI-Thy, QOL-Thyroid and ThyCAT), and six endocrine orbitopathy (GO-QOL, GO-QLS, TED-QOL, STED-QOL, TAO-QoL and Ox-TED). Only five questionnaires were at least developed, if not validated, in German, and five were developed in more than two languages.

Conclusions: ThyPRO and the ThyPRO-39 are the best-evaluated questionnaires for benign thyroid diseases. Alternatively, in hypothyroid patients, the adequately validated Thy-D-QoL can be used. For malignant thyroid diseases, the choice should be made individually, as all six questionnaires (THYCA-QoL, ThyCA-HRQOL, EORTC-Thy34, MDASI-Thy, QOL-Thyroid and ThyCAT) have different strengths and weaknesses. The GO-QOL is the best-validated questionnaire in endocrine orbitopathy. However, the TED-QOL is also suitable as a short-screening questionnaire for these patients.

Keywords: COSMIN; benign thyroid disease; endocrine orbitopathy; malignant thyroid disease.

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Conflict of interest statement

The authors have no relevant financial or nonfinancial interests to disclose.

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References

    1. Faggiano A, Del Prete M, Marciello F, Marotta V, Ramundo V, Colao A. Thyroid diseases in elderly. Minerva Endocrinol. 2011;36(3):211‐231. - PubMed
    1. Vanderpump MP. The epidemiology of thyroid disease. Br Med Bull. 2011;99:39‐51. - PubMed
    1. Leese GP, Flynn RV, Jung RT, Macdonald TM, Murphy MJ, Morris AD. Increasing prevalence and incidence of thyroid disease in Tayside, Scotland: the thyroid epidemiology audit and research study (TEARS). Clin Endocrinol. 2008;68(2):311‐316. - PubMed
    1. Scerrino G, Morfino G, Paladino NC, et al. Does thyroid surgery for Graves' disease improve health‐related quality of life? Surg Today. 2013;43(12):1398‐1405. - PubMed
    1. Watt T, Groenvold M, Rasmussen AK, et al. Quality of life in patients with benign thyroid disorders. A Review. Eur J Endocrinol. 2006;154(4):501‐510. - PubMed

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