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Review
. 2022 Sep;48(3):156.
doi: 10.3892/or.2022.8368. Epub 2022 Jul 20.

Anticancer effects of natural phytochemicals in anaplastic thyroid cancer (Review)

Yitian Li  1 , Jing Zhang  1 , Huihui Zhou  1 , Zhen Du  1
Affiliations
Review

Anticancer effects of natural phytochemicals in anaplastic thyroid cancer (Review)

Yitian Li et al. Oncol Rep. 2022 Sep.

Abstract

Anaplastic thyroid cancer (ATC) is an aggressive and lethal malignancy having a dismal prognosis. Phytochemicals are bioactive components obtained from plants that have been proven useful to treat numerous diseases. Phytochemicals are also an important source of novel anticancer drugs and an important area of research due to the numerous available candidates that can potentially treat cancers. This review discusses naturally occurring phytochemicals and their derivatives that show promising anticancer effects in anaplastic thyroid cancer. Anticancer effects include cell growth inhibition, induction of apoptosis, promoting cell cycle arrest, suppressing angiogenesis, modulating autophagy, and increasing the production of reactive oxygen species. Phytochemicals are not only prospective candidates in the therapy of anaplastic thyroid cancer but also exhibit potential as adjuvants to improve the anticancer effects of other drugs. Although some phytochemicals have excellent anticancer properties, drug resistance observed during the use of resveratrol and artemisinin in different anaplastic thyroid cancer cell lines is still a problem. Anaplastic thyroid cancer cells have several biological, clinical, and drug‑resistance features that differ from differentiated thyroid cancer cells. Phytochemicals such as resveratrol and quercetin exhibit different biological effects in anaplastic thyroid cancer and differentiated thyroid cancer. Tumor cells depend on increased aerobic glycolysis by mitochondrial oxidative phosphorylation to provide energy for their rapid growth, invasiveness, and drug resistance. Phytochemicals can alter signaling cascades, modulate the metabolic properties of cancer cells, and influence the mitochondrial membrane potential of anaplastic thyroid cancer cells. These findings enrich our knowledge of the anticancer effects of phytochemicals and highlight alternative therapies to prevent drug resistance in anaplastic thyroid cancer.

Keywords: adjuvant; anaplastic thyroid cancer; drug resistance; phytochemicals; resveratrol.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Table III.
Table III.
Summary of phytochemicals and their anticancer effects.
See this image and copyright information in PMC

References

    1. O'Neill JP, Shaha AR. Anaplastic thyroid cancer. Oral Oncol. 2013;49:702–706. doi: 10.1016/j.oraloncology.2013.03.440. - DOI - PubMed
    1. Saini S, Tulla K, Maker AV, Burman KD, Prabhakar BS. Therapeutic advances in anaplastic thyroid cancer: A current perspective. Mol Cancer. 2018;17:154. doi: 10.1186/s12943-018-0903-0. - DOI - PMC - PubMed
    1. Tesselaar MH, Crezee T, Schuurmans I, Gerrits D, Nagarajah J, Boerman OC, van Engen-van Grunsven I, Smit JWA, Netea-Maier RT, Plantinga TS. Digitalislike compounds restore hNIS expression and iodide uptake capacity in anaplastic thyroid cancer. J Nucl Med. 2018;59:780–786. doi: 10.2967/jnumed.117.200675. - DOI - PubMed
    1. Haugen BR, Sawka AM, Alexander EK, Bible KC, Caturegli P, Doherty GM, Mandel SJ, Morris JC, Nassar A, Pacini F, et al. American thyroid association guidelines on the management of thyroid nodules and differentiated thyroid cancer task force review and recommendation on the proposed renaming of encapsulated follicular variant papillary thyroid carcinoma without invasion to noninvasive follicular thyroid neoplasm with papillary-like nuclear features. Thyroid. 2017;27:481–483. doi: 10.1089/thy.2016.0628. - DOI - PubMed
    1. Haddad RI, Nasr C, Bischoff L, Busaidy NL, Byrd D, Callender G, Dickson P, Duh QY, Ehya H, Goldner W, et al. NCCN guidelines insights: Thyroid carcinoma, version 2.2018. J Natl Compr Cancer Netw. 2018;16:1429–1440. doi: 10.6004/jnccn.2018.0089. - DOI - PubMed

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