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. 2022 Aug;57(4):880-890.
doi: 10.1111/jre.13026.

Tamoxifen improves homeostasis in the peri-implant bone remodeling of osseointegrated titanium implants

Luiz Guilherme Fiorin  1   2 , Henrique Rinaldi Matheus  1   2 , Edilson Ervolino  3 , Elena Canciani  4 , Gaia Pellegrini  4 , Claudia Dellavia  4 , Carlo Maiorana  5 , Juliano Milanezi de Almeida  1   2
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Tamoxifen improves homeostasis in the peri-implant bone remodeling of osseointegrated titanium implants

Luiz Guilherme Fiorin et al. J Periodontal Res. 2022 Aug.

Abstract

Background: The purpose of this preclinical study was to evaluate the influence of tamoxifen (TAM) on the peri-implant bone remodeling of osseointegrated titanium implants in ovariectomized female rats.

Materials and methods: Seventy-two female rats underwent bilateral ovariectomy 20 weeks before implants placement. One titanium implant was inserted in each tibia of the animals. Six weeks following the implant surgery, animals were randomly divided into two experimental groups (n = 36), which received either saline solution (SS) or tamoxifen citrate (TAM) via gavage until euthanasia. Euthanasia was performed at 30, 60, and 90 days after the first gavage. Assessments of bone to implant contact (BIC), bone ingrowth percentage (BIN), morphological description of cellular and tissue reactions, immunohistochemistry for the detection of bone morphogenetic protein 2/4 (BMP2/4), runt-related transcription factor 2 (RUNX-2), osteocalcin (OCN) and tartrate-resistant acid phosphatase (TRAP), and bone chemical composition through scanning electron microscopy with energy-dispersive x-ray spectroscopy were performed.

Results: Tamoxifen group presented higher BIC, higher BIN, higher RUNX-2 and OCN, lower TRAP-positive cells/mm2 , and no differences regarding BMP-2/4 positive cells/mm2 than SS group in all periods. TAM group also showed higher Ca/P rate than SS group.

Conclusion: Tamoxifen enhanced the remodeling of the bone surrounding titanium implants in ovariectomized rats.

Keywords: bone remodeling; dental implants; selective estrogen receptor modulators; tamoxifen.

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References

REFERENCES

    1. Davies C, Pan H, Godwin J, et al. Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years after diagnosis of oestrogen receptor-positive breast cancer: ATLAS, a randomised trial. Lancet. 2013;381(9869):805-816.
    1. Ribnikar D, Sousa B, Cufer T, Cardoso F. Extended adjuvant endocrine therapy - A standard to all or some? Breast. 2017;32:112-118.
    1. Moon LY, Wakley GK, Turner RT. Dose-dependent effects of tamoxifen on long bones in growing rats: influence of ovarian status. Endocrinology. 1991;129(3):1568-1574.
    1. Zidan J, Keidar Z, Basher W, Israel O. Effects of tamoxifen on bone mineral density and metabolism in postmenopausal women with early-stage breast cancer. Med Oncol. 2004;21(2):117-121.
    1. Hadji P, Ziller M, Kieback DG, et al. The effect of exemestane or tamoxifen on markers of bone turnover: results of a German sub-study of the Tamoxifen Exemestane Adjuvant Multicentre (TEAM) trial. Breast. 2009;18(3):159-164.

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