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Randomized Controlled Trial
. 2022 Dec;61(8):4145-4154.
doi: 10.1007/s00394-022-02959-z. Epub 2022 Jul 20.

Efficacy of multi-strain probiotic along with dietary and lifestyle modifications on polycystic ovary syndrome: a randomised, double-blind placebo-controlled study

Ishwarpreet Kaur  1 , Vanita Suri  2 , Naresh Sachdeva  3 , Satya Vati Rana  4 , Bikas Medhi  5 , Nancy Sahni  6 , Jayesh Ahire  7 , Amarjeet Singh  8
Affiliations
Randomized Controlled Trial

Efficacy of multi-strain probiotic along with dietary and lifestyle modifications on polycystic ovary syndrome: a randomised, double-blind placebo-controlled study

Ishwarpreet Kaur et al. Eur J Nutr. 2022 Dec.

Abstract

Purpose: Effect of multi-strain probiotic along with dietary and lifestyle modifications in the management of polycystic ovary syndrome (PCOS) has rarely been reported. We thus aimed to investigate the effect of multi-strain probiotic (Lactobacillus acidophilus UBLA-34, L. rhamnosus UBLR-58, L. reuteri UBLRu-87 (each of 2 billion colony forming units (CFU)); L. plantarum UBLP-40, L. casei UBLC-42, L. fermentum UBLF-31, Bifidobacterium bifidum UBBB-55 (each of 1 billion CFU) and fructo-oligosaccharides (100 mg)) and dietary and lifestyle modifications on restoration of menstrual regularity, weight reduction, metabolic and hormonal profile in women with PCOS.

Methods: A 104 participants (age 18-40 years) were randomly allocated to receive probiotic or placebo capsules for 6 months. Baseline and end line assessment were performed for menstrual cycle regularity, ultrasonography scan for ovaries, total testosterone, dehydroepiandrosterone (DHEAS), insulin, luteinizing hormone/follicle stimulating hormone (LH/FSH) ratio, fasting blood sugar (FBS), homeostatic model assessment-insulin resistance (HOMA-IR), weight reduction, waist-/hip circumference (WC, HC), waist to hip ratio (WHR), and body mass index (BMI). Plasma lipopolysaccharide and effect of intervention on quality of life was investigated. Diet and exercise were controlled during the trial.

Results: Probiotic supplement along with dietary and lifestyle modifications significantly regularised menstrual cycle (p 0.023), improved levels of total testosterone (p 0.043), WC (p 0.030), WHR (p 0.027) and menstrual domain of quality of life (p 0.034) as compared to placebo. No adverse events related to study were reported.

Conclusion: Multi-strain probiotic along with dietary and lifestyle modifications were effective in the management of PCOS.

Trial registration: CTRI: CTRI/2016/07/007086, dated 13 July 2016.

Keywords: Lipopolysaccharide; Menstrual cycle; PCOS; Probiotic; Testosterone.

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References

    1. Teede H, Deeks A, Moran L (2010) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan. BMC Med 8:41. https://doi.org/10.1186/1741-7015-8-41 - DOI - PubMed - PMC
    1. Bulsara JP, Patel P, Soni A, Acharya S (2021) A review: brief insight into polycystic ovarian syndrome. Endocrine Metabolic Sci 3:100085. https://doi.org/10.1016/j.endmts.2021.100085 - DOI
    1. Aversa A, La Vignera S, Rago R, Gambineri A, Nappi RE, Calogero AE, Ferlin A (2020) Fundamental concepts and novel aspects of polycystic ovarian syndrome: expert consensus resolutions. Front Endocrinol 11:516. https://doi.org/10.3389/fendo.2020.00516 - DOI
    1. Global Burden of Disease (GBD) (2019) http://www.healthdata.org/results/gbd_summaries/2019/polycystic-ovarian-...
    1. Ganie MA, Vasudevan V, Wani IA, Baba MS, Arif T, Rashid A (2019) Epidemiology, pathogenesis, genetics & management of polycystic ovary syndrome in India. Indian J Med Res 150(4):333–344. https://doi.org/10.4103/ijmr.IJMR_1937_17 - DOI - PubMed - PMC

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