Mosaic loss of Y chromosome during aging

Andreas Zeiher^{1

2}, Thomas Braun^{2

3}

Affiliations

¹ Institute of Cardiovascular Regeneration, Goethe University, Frankfurt, Germany.
² German Center for Cardiovascular Research DZHK, Partner Site Rhine-Main, Berlin, Germany.
³ Max Planck Institute for Heart and Lung Research, Department of Cardiac Development and Remodeling, Bad Nauheim, Germany.

Comment

Andreas Zeiher et al. Science. 2022.

. 2022 Jul 15;377(6603):266-267.

doi: 10.1126/science.add0839. Epub 2022 Jul 14.

Andreas Zeiher^{1

2}, Thomas Braun^{2

3}

¹ Institute of Cardiovascular Regeneration, Goethe University, Frankfurt, Germany.
² German Center for Cardiovascular Research DZHK, Partner Site Rhine-Main, Berlin, Germany.
³ Max Planck Institute for Heart and Lung Research, Department of Cardiac Development and Remodeling, Bad Nauheim, Germany.

Abstract

Spread of Y chromosome aneuploidy in myeloid cells with age promotes cardiac fibrosis.

Hematopoietic loss of Y chromosome leads to cardiac fibrosis and heart failure mortality.
Sano S, Horitani K, Ogawa H, Halvardson J, Chavkin NW, Wang Y, Sano M, Mattisson J, Hata A, Danielsson M, Miura-Yura E, Zaghlool A, Evans MA, Fall T, De Hoyos HN, Sundström J, Yura Y, Kour A, Arai Y, Thel MC, Arai Y, Mychaleckyj JC, Hirschi KK, Forsberg LA, Walsh K. Sano S, et al. Science. 2022 Jul 15;377(6603):292-297. doi: 10.1126/science.abn3100. Epub 2022 Jul 14. Science. 2022. PMID: 35857592 Free PMC article.