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Comment
. 2022 Jul 19;119(29):e2208744119.
doi: 10.1073/pnas.2208744119. Epub 2022 Jul 11.

Alcohol, neuronal plasticity, and mitochondrial trafficking

John Hernandez  1 , Karla R Kaun  1
Affiliations
Comment

Alcohol, neuronal plasticity, and mitochondrial trafficking

John Hernandez et al. Proc Natl Acad Sci U S A. .

Erratum in

No abstract available

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Conflict of interest statement

The authors declare no competing interest.

Figures

Fig. 1.
Fig. 1.
Cross-assay and cross-species approaches to understanding how alcohol affects the brain. Knabbe et al. (3) used proteomic approaches in postnatal-day-30 mice to examine the impacts of acute alcohol exposure at a critical developmental stage. Subsequently, candidate synaptic proteins were examined in the primary somatosensory (S1) and motor (M1) cortex. Alcohol exposure increased synaptic boutons loss, decreased axon initial segment length, and increased mitochondria motility. When mitochondrial trafficking in dopamine neurons is disrupted, adult Drosophila are unable to form appetitive alcohol memories.
See this image and copyright information in PMC

Comment on

  • Single-dose ethanol intoxication causes acute and lasting neuronal changes in the brain.
    Knabbe J, Protzmann J, Schneider N, Berger M, Dannehl D, Wei S, Strahle C, Tegtmeier M, Jaiswal A, Zheng H, Krüger M, Rohr K, Spanagel R, Bilbao A, Engelhardt M, Scholz H, Cambridge SB. Knabbe J, et al. Proc Natl Acad Sci U S A. 2022 Jun 21;119(25):e2122477119. doi: 10.1073/pnas.2122477119. Epub 2022 Jun 14. Proc Natl Acad Sci U S A. 2022. PMID: 35700362 Free PMC article.

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