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Comment
. 2022 Jul 26;119(30):e2209130119.
doi: 10.1073/pnas.2209130119. Epub 2022 Jul 18.

In SARS-CoV-2, astrocytes are in it for the long haul

Shuhan Huang  1   2   3 , Gord Fishell  1   2
Affiliations
Comment

In SARS-CoV-2, astrocytes are in it for the long haul

Shuhan Huang et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no competing interest.

Figures

Fig. 1.
Fig. 1.
Astrocytes are the primary targets of SARS-CoV-2 in the brain. SARS-CoV-2 is shown to preferentially infect astrocytes over neurons in primary and organoid cortical cultures, resulting in astrocyte reactivation and non-cell-autonomous neuronal death. Furthermore, BSG/CD147 and DPP4 are found to be key molecular mediators of SARS-CoV-2 infection in cortical astrocytes. Abbreviations: BBB, blood–brain barrier; CSF, cerebrospinal fluid; CVO, circumventricular organs.
See this image and copyright information in PMC

Comment on

  • Tropism of SARS-CoV-2 for human cortical astrocytes.
    Andrews MG, Mukhtar T, Eze UC, Simoneau CR, Ross J, Parikshak N, Wang S, Zhou L, Koontz M, Velmeshev D, Siebert CV, Gemenes KM, Tabata T, Perez Y, Wang L, Mostajo-Radji MA, de Majo M, Donohue KC, Shin D, Salma J, Pollen AA, Nowakowski TJ, Ullian E, Kumar GR, Winkler EA, Crouch EE, Ott M, Kriegstein AR. Andrews MG, et al. Proc Natl Acad Sci U S A. 2022 Jul 26;119(30):e2122236119. doi: 10.1073/pnas.2122236119. Epub 2022 Jul 12. Proc Natl Acad Sci U S A. 2022. PMID: 35858406 Free PMC article.

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