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Case Reports
. 2022 Oct:66:104035.
doi: 10.1016/j.msard.2022.104035. Epub 2022 Jul 5.

Fulminant neuromyelitis optica spectrum disorder (NMOSD) following COVID-19 vaccination: A need for reconsideration?

Ali Motahharynia  1 , Saba Naghavi  2 , Vahid Shaygannejad  2 , Iman Adibi  3
Affiliations
Case Reports

Fulminant neuromyelitis optica spectrum disorder (NMOSD) following COVID-19 vaccination: A need for reconsideration?

Ali Motahharynia et al. Mult Scler Relat Disord. 2022 Oct.

Abstract

During the coronavirus disease 2019 (COVID-19) pandemic, mass vaccination was a beneficial strategy in many countries. Nevertheless, reports of serious complications such as postvaccination neuromyelitis optica spectrum disorder (NMOSD) raised concerns about the safety of vaccines. Anamnart and colleagues explained postvaccination NMOSD following different vaccines, including COVID-19. To emphasize the message of this article, in this letter, we present a unique case of postvaccination NMOSD with a fulminant and fatal course, which may show a plausible relationship between COVID-19 vaccination and triggering anti-aquaporin-4 antibody (AQP4-Ab).

Keywords: COVID-19 vaccine; NMOSD; Neuromyelitis optica spectrum disorder; Postvaccination.

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Conflict of interest statement

Declaration of Interests The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig 1
Fig. 1
Spinal cord magnetic resonance imaging (MRI) following CVOID-19 vaccination. Cervical MRI demonstrated a low T1-weighted long segment hemorrhagic lesion (A) and a high T2-weighted long segment myelitis (B) with peripheral enhancement in post-Gadolinium T1- weighted image (C). Thoracic T2-weighted MR image determined long segment myelitis (D).
See this image and copyright information in PMC

Comment in

  • Fatal neuromyelitis optica after COVID-19 vaccination.
    Boldrini VO, Yasuda CL. Boldrini VO, et al. Mult Scler Relat Disord. 2022 Dec;68:104089. doi: 10.1016/j.msard.2022.104089. Epub 2022 Aug 11. Mult Scler Relat Disord. 2022. PMID: 35987109 Free PMC article. No abstract available.

References

    1. Anamnart C, Tisavipat N, Owattanapanich W, Apiwattanakul M, Savangned P, Prayoonwiwat N, et al. Newly diagnosed neuromyelitis optica spectrum disorders following vaccination: Case report and systematic review. Mult. Scler. Relat. Disord. 2022;58 https://linkinghub.elsevier.com/retrieve/pii/S2211034821006805 Available from: - PubMed
    1. Awad A, Stüve O. Review: Cyclophosphamide in multiple sclerosis–Scientific rationale, history and novel treatment paradigms. Ther. Adv. Neurol. Disord. 2009;2(6):357–368. http://journals.sagepub.com/doi/10.1177/1756285609344375 Available from: - DOI - PMC - PubMed
    1. Krumbholz M, Hofstadt-van Oy U, Angstwurm K, Kleiter I, Jarius S, Paul F, et al. Very late-onset neuromyelitis optica spectrum disorder beyond the age of 75. J. Neurol. 2015;262(5):1379–1384. http://link.springer.com/10.1007/s00415-015-7766-8 Available from: - DOI - PMC - PubMed
    1. Wingerchuk DM, Banwell B, Bennett JL, Cabre P, Carroll W, Chitnis T, et al. International consensus diagnostic criteria for neuromyelitis optica spectrum disorders. Neurology. 2015;85(2):177–189. https://www.neurology.org/lookup/doi/10.1212/WNL.0000000000001729 Available from: - DOI - PMC - PubMed