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. 2022 Jul 20;23(1):257.
doi: 10.1186/s12882-022-02884-7.

Low-grade albuminuria and its relationship with cardiovascular disease risk in hypertensive and diabetic patients in primary health care

Ramon Augusto Ferreira de Souza  1 , Eunice Ferreira da Silva  1 , Deíse Moura de Oliveira  1 , Renata Maria Colodette  2 , Rosângela Minardi Mitre Cotta  3 , Luciana Saraiva da Silva  4 , Tiago Ricardo Moreira  5
Affiliations

Low-grade albuminuria and its relationship with cardiovascular disease risk in hypertensive and diabetic patients in primary health care

Ramon Augusto Ferreira de Souza et al. BMC Nephrol. .

Abstract

Objective: To evaluate the presence of LGA and the relationship with the 10-year risk of a cardiovascular event in hypertensive and diabetic patients in Primary Health Care.

Study design: The study design used is cross-sectional.

Methods: This study was based on the application of questionnaires, anthropometric measurements, and laboratory tests carried out from August 2017 to April 2018. Logistic regression was used to evaluate the odds ratio of the explanatory variables in relation to the highest tercile of LGA. The Framingham risk score was used to assess the 10-year risk of cardiovascular event. The comparison of this score with the LGA terciles was analyzed using ANOVA.

Results: An increase in the 10-year risk of cardiovascular event score was observed with an increasing LGA tercile, and this pattern prevailed after adjusting for confounding variables.

Conclusion: An association between LGA and the 10-year risk of cardiovascular event was observed in a representative sample of hypertensive and diabetic patients.

Keywords: Albuminuria; Cardiovascular diseases; Diabetes Mellitus; Hypertension; Risk factors.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Distribution of the 10-year Framingham risk by gender and tercile of low-grade albuminuria. The 10-year risk of coronary heart disease according to the Framingham score: > 20% = high-risk; 10–20% = intermediate-risk, and < 10% = low-risk instances
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