Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Jul 20;23(1):257.
doi: 10.1186/s12882-022-02884-7.

Low-grade albuminuria and its relationship with cardiovascular disease risk in hypertensive and diabetic patients in primary health care

Ramon Augusto Ferreira de Souza  1 , Eunice Ferreira da Silva  1 , Deíse Moura de Oliveira  1 , Renata Maria Colodette  2 , Rosângela Minardi Mitre Cotta  3 , Luciana Saraiva da Silva  4 , Tiago Ricardo Moreira  5
Affiliations

Low-grade albuminuria and its relationship with cardiovascular disease risk in hypertensive and diabetic patients in primary health care

Ramon Augusto Ferreira de Souza et al. BMC Nephrol. .

Abstract

Objective: To evaluate the presence of LGA and the relationship with the 10-year risk of a cardiovascular event in hypertensive and diabetic patients in Primary Health Care.

Study design: The study design used is cross-sectional.

Methods: This study was based on the application of questionnaires, anthropometric measurements, and laboratory tests carried out from August 2017 to April 2018. Logistic regression was used to evaluate the odds ratio of the explanatory variables in relation to the highest tercile of LGA. The Framingham risk score was used to assess the 10-year risk of cardiovascular event. The comparison of this score with the LGA terciles was analyzed using ANOVA.

Results: An increase in the 10-year risk of cardiovascular event score was observed with an increasing LGA tercile, and this pattern prevailed after adjusting for confounding variables.

Conclusion: An association between LGA and the 10-year risk of cardiovascular event was observed in a representative sample of hypertensive and diabetic patients.

Keywords: Albuminuria; Cardiovascular diseases; Diabetes Mellitus; Hypertension; Risk factors.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Distribution of the 10-year Framingham risk by gender and tercile of low-grade albuminuria. The 10-year risk of coronary heart disease according to the Framingham score: > 20% = high-risk; 10–20% = intermediate-risk, and < 10% = low-risk instances
See this image and copyright information in PMC

References

    1. Cusumano A, Garcia GG, Di Gioia C, Hermida O, Lavorato C. Registro Latino-Americano de Diálise e Transplante. The Latin American Dialysis and transplantation registry (RLDT) annual report 2004. Ethn Dis [Internet]. 2006;16(2 Suplemento 2):S2-10–3. Available from. 10.1080/08860220600925693. - PubMed
    1. Jha V, Garcia-Garcia G, Iseki K, Li Z, Naicker S, Plattner B, et al. Chronic kidney disease: Global dimension and perspectives. Lancet (London, England) [Internet] 2013;382(9888):260–272. doi: 10.1016/S0140-6736(13)60687-X. - DOI - PubMed
    1. Barroso WKS, Rodrigues CIS, Bortolotto LA, Mota-Gomes MA, Brandão AA, de Magalhães Feitosa AD, et al. Diretrizes Brasileiras de Hipertensão Arterial - 2020. Arq Bras Cardiol [Internet]. 2021 [cited 2021 Jul 16];116(3):516–658. Available from: https://abccardiol.org/article/diretrizes-brasileiras-de-hipertensao-art... - PMC - PubMed
    1. Lieb W, Mayer B, Stritzke J, Doering A, Hense HW, Loewel H, et al. Association of low-grade urinary albumin excretion with left ventricular hypertrophy in the general population. Nephrol Dial Transplant [Internet] 2006;21(10):2780–2787. doi: 10.1093/ndt/gfl364. - DOI - PubMed
    1. Ärnlöv J, Evans JC, Meigs JB, Wang TJ, Fox CS, Levy D, et al. Low-grade albuminuria and incidence of cardiovascular disease events in nonhypertensive and nondiabetic individuals: The framingham heart study. Circulation. 2005;112(7):969–975. doi: 10.1161/CIRCULATIONAHA.105.538132. - DOI - PubMed

Publication types