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Case Reports
. 2022 Jul 15;10(7):e5959.
doi: 10.1002/ccr3.5959. eCollection 2022 Jul.

Case of a lung collision tumor consisting of squamous cell carcinoma of the lung and diffuse large B-cell lymphoma

Masato Sasaki  1 , Kayo Sakon  1 , Kaede Tanaka  1 , Akitoshi Okada  1 , Takeshi Ikeda  2 , Takaaki Koshiji  1
Affiliations
Case Reports

Case of a lung collision tumor consisting of squamous cell carcinoma of the lung and diffuse large B-cell lymphoma

Masato Sasaki et al. Clin Case Rep. .

Abstract

Among the reports of malignant collision tumors, collision tumors consisting of lung cancer and malignant lymphoma are extremely rare. We report case of a lung collision tumor consisting of squamous cell carcinoma of the lung and diffuse large B-cell lymphoma.

Keywords: collision tumor; double tumor; lung cancer; malignant lymphoma; nodular shadow.

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Conflict of interest statement

The authors have stated that they have no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
Findings of Chest radiography, CT of the chest and FDG‐PET. (A) Chest radiography: A nodular shadow approximately 2 cm in maximum diameter was found in the upper right lung field. (B) CT of the chest: A 24 × 21 × 18 mm nodule with a cavity was found in the first segment of the upper right lobe. (C) FDG‐PET: SUV max accumulation of 9.4 was observed in the nodule in the right upper lobe. In addition to strong accumulation in the left cervical lymph nodes, accumulation also occurred in both axillary lesions, near the pancreatic head, in both external iliac arteries, and in the right inguinal lymph nodes
FIGURE 2
FIGURE 2
Pathological findings of lung tumor. (A) (hematoxylin and eosin stain, x20): Pathological findings: Poorly differentiated squamous cell carcinoma of the lung and malignant lymphoma‐like lesions were observed in the same foci (upper). (B and C) Immunohistochemical staining revealed that CD79a (B, ×20), a B‐cell marker, was positive, indicating diffuse large B‐cell lymphoma. In addition, the area where AE1AE3 (C, ×20), which is an epithelial marker, was positive and the area where CD79a was positive overlapped, suggesting that squamous cell carcinoma and malignant lymphoma were both present in the same lesion
See this image and copyright information in PMC

References

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